| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
IGF1R |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the IGF1R antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This IGF1R antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P08069 |
| Purity: |
Purified |
| Description: |
Cleavage of the precursor generates alpha and beta subunits, It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival, The protein possess tyrosine kinase activity, The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events |
| Immunogen: |
A portion of amino acids 19-51 from the human protein was used as the immunogen for this IGF1R antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the IGF1R antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
IGF1R |
| Short name: |
IGF1R Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
insulin-like growth factor 1 receptor (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD221 and IGFIR and IGFR and JTK13, Cell surfaces, IGF1R and IDBG-31432 and ENSG00000140443 and 3480, IGF1R and IDBG-628659 and ENSBTAG00000021527 and 281848, Igf1r and IDBG-192339 and ENSMUSG00000005533 and 16001, this GO :0001965 and G-protein alpha-subunit binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005010 and insulin-like growth factor-activated receptor activity and molecular function this GO :0005158 and insulin receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005520 and insulin-like growth factor binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007409 and axonogenesis and biological process this GO :0007420 and brain development and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008544 and epidermis development and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0010656 and negative regulation of muscle cell apoptotic process and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0001965 : G-protein alpha-subunit binding, this GO :0001965 : G-protein alpha-subunit binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0005010 : insulin-like growth factor-activated receptor activity and also this GO :0005158 : insulin receptor binding and also this GO :0005515 : protein binding and also this GO :0005520 : insulin-like growth factor binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0005010 : insulin-like growth factor-activated receptor activity, this GO :0005158 : insulin receptor binding, this GO :0005515 : protein binding, this GO :0005520 : insulin-like growth factor binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0031994 : insulin-like growth factor I binding, this GO :0042802 : identical protein binding, this GO :0043548 : phosphatidylinositol 3-kinase binding, this GO :0043559 : insulin binding, this GO :0043560 : insulin receptor substrate binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0031994 : insulin-like growth factor I binding and also this GO :0042802 : identical protein binding and also this GO :0043548 : phosphatidylinositol 3-kinase binding and also this GO :0043559 : insulin binding and also this GO :0043560 : insulin receptor substrate binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030010 and establishment of cell polarity and biological process this GO :0030238 and male sex determination and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030879 and mammary gland development and biological process this GO :0031017 and exocrine pancreas development and biological process this GO :0031175 and neuron projection development and biological process this GO :0031994 and insulin-like growth factor I binding and molecular function this GO :0032467 and positive regulation of cytokinesis and biological process this GO :0033197 and response to vitamin E and biological process this GO :0038083 and peptidyl-tyrosine autophosphorylation and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043235 and receptor complex and cellular component this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0043559 and insulin binding and molecular function this GO :0043560 and insulin receptor substrate binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0046328 and regulation of JNK cascade and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0051054 and positive regulation of DNA metabolic process and biological process this GO :0051262 and protein tetramerization and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051389 and inactivation of MAPKK activity and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0051898 and negative regulation of protein kinase B signaling and biological process this GO :0060740 and prostate gland epithelium morphogenesis and biological process this GO :0090031 and positive regulation of steroid hormone biosynthetic process and biological process, insulin-like growth factor 1 receptor |
| Identity: |
5465 |
| Gene: |
IGF1R |
More about : IGF1R |
| Long gene name: |
insulin like growth factor 1 receptor |
| Synonyms gene name: |
insulin-like growth factor 1 receptor |
| Synonyms: |
JTK13 CD221 IGFIR MGC18216 IGFR |
| Locus: |
15q26, 3 |
| Discovery year: |
1988-07-07 |
| GenBank acession: |
M69229 |
| Entrez gene record: |
3480 |
| Pubmed identfication: |
1316909 |
| RefSeq identity: |
NM_000875 |
| Classification: |
CD molecules Fibronectin type III domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000149851 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_1055 |