| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SPHK2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the SPHK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SPHK2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9NRA0 |
| Purity: |
Purified |
| Description: |
In contrast, S1P subsequently signals through cell surface G protein-coupled receptors, SphK is an important signaling enzyme which is activated by diverse agents, SphK-1 and SphK-2, SphK-1 has been shown to mediate cell growth, SphK-2 increases apoptosis, Two SphK isotypes, agents activating G protein-coupled receptors, and both isotypes are ubiquitously expressed, and cellular transformation, and immunoglobulin receptors, and is upregulated in a variety of human tumors, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720, as well as intracellularly, creating the bioactive lipid sphingosine-1-phosphate (S1P), have been cloned, including growth factors that signal through receptor tyrosine kinases, motility and differentiation, prevention of apoptosis, survival, to modulate cell proliferation, Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine |
| Immunogen: |
A portion of amino acids 1-30 from the human protein was used as the immunogen for this SPHK2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SPHK2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SPHK2 |
| Short name: |
SPHK2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sphin this GO sine kinase 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
D-erythro-sphin this GO sine kinase activity, Plasma membranes, SPHK2 and IDBG-60754 and ENSG00000063176 and 56848, SPHK2 and IDBG-640229 and ENSBTAG00000009872 and 533103, Sphk2 and IDBG-184179 and ENSMUSG00000057342 and 56632, this GO :0001568 and blood vessel development and biological process this GO :0003951 and NAD+ kinase activity and molecular function this GO :0004143 and diacylglycerol kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005765 and lysosomal membrane and cellular component this GO :0005829 and cytosol and cellular component this GO :0006665 and sphin this GO lipid metabolic process and biological process this GO :0006669 and sphinganine-1-phosphate biosynthetic process and biological process this GO :0006670 and sphin this GO sine metabolic process and biological process this GO :0007205 and protein kinase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0007420 and brain development and biological process this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008481 and sphinganine kinase activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016310 and phosphorylation and biological process this GO :0017016 and Ras GTPase binding and molecular function this GO :0017050 and D-erythro-sphin this GO sine kinase activity and molecular function this GO :0030148 and sphin this GO lipid biosynthetic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0046834 and lipid phosphorylation and biological process, this GO :0003951 : NAD+ kinase activity, this GO :0003951 : NAD+ kinase activity and also this GO :0004143 : diacylglycerol kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008481 : sphinganine kinase activity and also this GO :0017016 : Ras GTPase binding and also this GO :0017050 : D-erythro-sphin this GO sine kinase activity, this GO :0004143 : diacylglycerol kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008481 : sphinganine kinase activity, this GO :0017016 : Ras GTPase binding, this GO :0017050 : D-erythro-sphin this GO sine kinase activity, sphin this GO sine kinase 2 |
| Identity: |
18859 |
| Gene: |
SPHK2 |
More about : SPHK2 |
| Long gene name: |
sphingosine kinase 2 |
| Locus: |
19q13, 33 |
| Discovery year: |
2002-07-05 |
| GenBank acession: |
AF245447 |
| Entrez gene record: |
56848 |
| Pubmed identfication: |
10751414 17895250 |
| Havana BLAST/BLAT: |
OTTHUMG00000183318 |