| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
P-Glycoprotein (ABCB1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the P-Glycoprotein antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This P-Glycoprotein antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P08183 |
| Purity: |
Purified |
| Description: |
ABC genes are divided into seven distinct subfamilies (ABC1, ABC proteins transport various molecules across extra- and intra-cellular membranes, ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity, ALD, GCN20, It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs, MDR/TAP, MRP, Members of the MDR/TAP subfamily are involved in multidrug resistance, OABP, This protein also functions as a transporter in the blood-brain barrier, This protein is a member of the MDR/TAP subfamily, White), The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters |
| Immunogen: |
A portion of amino acids 647-677 from the human protein was used as the immunogen for this P-Glycoprotein antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the P-Glycoprotein antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
P-Glycoprotein (ABCB1) |
| Short name: |
P-Glycoprotein (ABCB1) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
P-Glycoprotein (ABCB1) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
40 |
| Gene: |
ABCB1 |
More about : ABCB1 |
| Long gene name: |
ATP binding cassette subfamily B member 1 |
| Synonyms gene: |
PGY1 MDR1 CLCS |
| Synonyms gene name: |
colchicin sensitivity ATP-binding cassette, member 1 , sub-family B (MDR/TAP) |
| Synonyms: |
P-gp CD243 GP170 ABC20 |
| Synonyms name: |
multidrug resistance protein 1 |
| Locus: |
7q21, 12 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M14758 |
| Entrez gene record: |
5243 |
| Pubmed identfication: |
3027054 |
| RefSeq identity: |
NM_000927 |
| Classification: |
CD molecules ATP binding cassette subfamily B |
| Havana BLAST/BLAT: |
OTTHUMG00000023393 |