| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
p-PTEN (pS385) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, DB |
| Recommended dilutions: |
Dot blot: 1:500 |
| Notes: |
Titration of the p-PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This p-PTEN antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P60484 |
| Purity: |
Antigen affinity |
| Description: |
It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases, It negatively regulates intracellular levels of phosphatidylinositol-3, The protein encoded this gene is a phosphatidylinositol-3, Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates, 4, 4, 5-trisphosphate 3-phosphatase, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway, This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency |
| Immunogen: |
This p-PTEN antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS385 of human PTEN |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the p-PTEN antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
p-PTEN (pS385) |
| Short name: |
p-PTEN Antibody (pS385) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
p-phosphatase and tensin homolog (Antibody to) (pS385) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
10q23del and BZS and CWS1 and DEC and GLM2 and MHAM and MMAC1 and PTEN1 and TEP1, PTEN and IDBG-637256 and ENSBTAG00000009498 and 540786, PTEN and IDBG-81409 and ENSG00000171862 and 5728, Pten and IDBG-158878 and ENSMUSG00000013663 and 19211, nuclei, phosphatidylinositol-3, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0000287 and magnesium ion binding and molecular function this GO :0001525 and angiogenesis and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0002902 and regulation of B cell apoptotic process and biological process this GO :0004438 and phosphatidylinositol-3-phosphatase activity and molecular function this GO :0004721 and phosphoprotein phosphatase activity and molecular function this GO :0004722 and protein serine/threonine phosphatase activity and molecular function this GO :0004725 and protein tyrosine phosphatase activity and molecular function this GO :0005161 and platelet-derived growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006470 and protein dephosphorylation and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006661 and phosphatidylinositol biosynthetic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0007092 and activation of mitotic anaphase-promoting complex activity and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007270 and neuron-neuron synaptic transmission and biological process this GO :0007416 and synapse assembly and biological process this GO :0007417 and central nervous system development and biological process this GO :0007507 and heart development and biological process this GO :0007568 and aging and biological process this GO :0007584 and response to nutrient and biological process this GO :0007611 and learning or memory and biological process this GO :0007613 and memory and biological process this GO :0007626 and locomotory behavior and biological process this GO :0008138 and protein tyrosine/serine/threonine phosphatase activity and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008289 and lipid binding and molecular function this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009749 and response to glucose and biological process this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0010033 and response to organic substance and biological process this GO :0010035 and response to inorganic substance and biological process this GO :0010043 and response to zinc ion and biological process this GO :0010975 and regulation of neuron projection development and biological process this GO :0010997 and anaphase-promoting complex binding and molecular function this GO :0014067 and negative regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016311 and dephosphorylation and biological process this GO :0016314 and phosphatidylinositol-3, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004438 : phosphatidylinositol-3-phosphatase activity and also this GO :0004721 : phosphoprotein phosphatase activity and also this GO :0004722 : protein serine/threonine phosphatase activity and also this GO :0004725 : protein tyrosine phosphatase activity and also this GO :0005161 : platelet-derived growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0008138 : protein tyrosine/serine/threonine phosphatase activity and also this GO :0008289 : lipid binding and also this GO :0010997 : anaphase-promoting complex binding and also this GO :0016314 : phosphatidylinositol-3, this GO :0004438 : phosphatidylinositol-3-phosphatase activity, this GO :0004721 : phosphoprotein phosphatase activity, this GO :0004722 : protein serine/threonine phosphatase activity, this GO :0004725 : protein tyrosine phosphatase activity, this GO :0005161 : platelet-derived growth factor receptor binding, this GO :0005515 : protein binding, this GO :0008138 : protein tyrosine/serine/threonine phosphatase activity, this GO :0008289 : lipid binding, this GO :0010997 : anaphase-promoting complex binding, this GO :0016314 : phosphatidylinositol-3, this GO :0016791 : phosphatase activity, this GO :0019899 : enzyme binding, this GO :0019901 : protein kinase binding, this GO :0030165 : PDZ domain binding, this GO :0051717 : inositol-1, this GO :0051800 : phosphatidylinositol-3, 3, 3, 3, 4, 4, 4, 4, 4, 4, 4-bisphosphate 3-phosphatase activity, 4-bisphosphate 3-phosphatase activity, 4-bisphosphate 3-phosphatase activity and molecular function this GO :0051895 and negative regulation of focal adhesion assembly and biological process this GO :0051898 and negative regulation of protein kinase B signaling and biological process this GO :0060024 and rhythmic synaptic transmission and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060074 and synapse maturation and biological process this GO :0060134 and prepulse inhibition and biological process this GO :0060179 and male mating behavior and biological process this GO :0060291 and long-term synaptic potentiation and biological process this GO :0060292 and long term synaptic depression and biological process this GO :0060736 and prostate gland growth and biological process this GO :0060997 and dendritic spine morphogenesis and biological process this GO :0061002 and negative regulation of dendritic spine morphogenesis and biological process this GO :0090071 and negative regulation of ribosome biogenesis and biological process this GO :0090344 and negative regulation of cell aging and biological process this GO :0090394 and negative regulation of excitatory postsynaptic membrane potential and biological process this GO :0097105 and presynaptic membrane assembly and biological process this GO :0097107 and postsynaptic density assembly and biological process this GO :2000060 and positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process and biological process this GO :2000134 and negative regulation of G1/S transition of mitotic cell cycle and biological process this GO :2000463 and positive regulation of excitatory postsynaptic membrane potential and biological process this GO :2000808 and negative regulation of synaptic vesicle clustering and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, 5-tetrakisphosphate 3-phosphatase activity, 5-tetrakisphosphate 3-phosphatase activity and also this GO :0051800 : phosphatidylinositol-3, 5-tetrakisphosphate 3-phosphatase activity and molecular function this GO :0051726 and regulation of cell cycle and biological process this GO :0051800 and phosphatidylinositol-3, 5-trisphosphate 3-phosphatase activity, 5-trisphosphate 3-phosphatase activity and also this GO :0016791 : phosphatase activity and also this GO :0019899 : enzyme binding and also this GO :0019901 : protein kinase binding and also this GO :0030165 : PDZ domain binding and also this GO :0051717 : inositol-1, 5-trisphosphate 3-phosphatase activity and molecular function this GO :0016477 and cell migration and biological process this GO :0016605 and PML body and cellular component this GO :0016791 and phosphatase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0021542 and dentate gyrus development and biological process this GO :0021955 and central nervous system neuron axonogenesis and biological process this GO :0030165 and PDZ domain binding and molecular function this GO :0030336 and negative regulation of cell migration and biological process this GO :0031175 and neuron projection development and biological process this GO :0031642 and negative regulation of myelination and biological process this GO :0031647 and regulation of protein stability and biological process this GO :0031658 and negative regulation of cyclin-dependent protein kinase activity involved in G1/S and biological process this GO :0032286 and central nervous system myelin maintenance and biological process this GO :0032355 and response to estradiol and biological process this GO :0032535 and regulation of cellular component size and biological process this GO :0033032 and regulation of myeloid cell apoptotic process and biological process this GO :0033198 and response to ATP and biological process this GO :0033555 and multicellular organismal response to stress and biological process this GO :0035176 and social behavior and biological process this GO :0035335 and peptidyl-tyrosine dephosphorylation and biological process this GO :0035749 and myelin sheath adaxonal region and cellular component this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042493 and response to drug and biological process this GO :0042711 and maternal behavior and biological process this GO :0042995 and cell projection and cellular component this GO :0043005 and neuron projection and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043197 and dendritic spine and cellular component this GO :0043220 and Schmidt-Lanterman incisure and cellular component this GO :0043491 and protein kinase B signaling and biological process this GO :0043542 and endothelial cell migration and biological process this GO :0043647 and inositol phosphate metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045211 and postsynaptic membrane and cellular component this GO :0045471 and response to ethanol and biological process this GO :0045475 and locomotor rhythm and biological process this GO :0045792 and negative regulation of cell size and biological process this GO :0046621 and negative regulation of organ growth and biological process this GO :0046685 and response to arsenic-containing substance and biological process this GO :0046855 and inositol phosphate dephosphorylation and biological process this GO :0046856 and phosphatidylinositol dephosphorylation and biological process this GO :0048008 and platelet-derived growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048738 and cardiac muscle tissue development and biological process this GO :0048853 and forebrain morphogenesis and biological process this GO :0048854 and brain morphogenesis and biological process this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0050765 and negative regulation of pha this GO cytosis and biological process this GO :0050771 and negative regulation of axonogenesis and biological process this GO :0050821 and protein stabilization and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051717 and inositol-1, phosphatase and tensin homolog |
| Identity: |
9588 |
| Gene: |
PTEN |
More about : PTEN |
| Long gene name: |
phosphatase and tensin homolog |
| Synonyms gene: |
BZS MHAM |
| Synonyms: |
MMAC1 TEP1 PTEN1 |
| Synonyms name: |
mutated in multiple advanced cancers 1 |
| Locus: |
10q23, 31 |
| Discovery year: |
1997-04-21 |
| GenBank acession: |
U92436 |
| Entrez gene record: |
5728 |
| Pubmed identfication: |
9090379 |
| RefSeq identity: |
NM_000314 |
| Classification: |
Phosphoinositide phosphatases PTEN protein phosphatases C2 tensin-type domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000018688 |
| Locus Specific Databases: |
LRG_311 |