| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
BMPR1A |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IF, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the BMPR1A antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This BMPR1A antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P36894 |
| Purity: |
Purified |
| Description: |
ACVR1 and ACVR2, BMP receptors are highly expressed in bone, BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, Both activins and TGF-beta transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors, Germline mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II) have been reported in patients with primary pulmonary hypertension (PPH), The ligands of these receptors are members of the TGF-beta superfamily, These receptors are also closely related to the activin receptors, Type II receptors bind ligands in the absence of type I receptors, and may be a factor in the progession of Cowden-like syndrome, but they require their respective type I receptors for signaling, disrupt normal dorsal/ventral patterning during limb development, heart and liver tissue, skeletal muscle, whereas type I receptors require their respective type II receptors for ligand binding, The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2 |
| Immunogen: |
A portion of amino acids 21-51 from the human protein was used as the immunogen for this BMPR1A antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the BMPR1A antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
BMPR1A |
| Short name: |
BMPR1A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
classification IA (Antibody to), bone morphogenetic protein receptor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
10q23del and ACVRLK3 and ALK3 and CD292 and SKR5, BMPR1A and IDBG-81081 and ENSG00000107779 and 657, BT, Bmpr1a and IDBG-149689 and ENSMUSG00000021796 and 12166, Cell surfaces, DNA-templated and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0048339 and paraxial mesoderm development and biological process this GO :0048352 and paraxial mesoderm structural organization and biological process this GO :0048368 and lateral mesoderm development and biological process this GO :0048378 and regulation of lateral mesodermal cell fate specification and biological process this GO :0048382 and mesendoderm development and biological process this GO :0048568 and embryonic organ development and biological process this GO :0048589 and developmental growth and biological process this GO :0048598 and embryonic morphogenesis and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0050768 and negative regulation of neurogenesis and biological process this GO :0051216 and cartilage development and biological process this GO :0060021 and palate development and biological process this GO :0060391 and positive regulation of SMAD protein import into nucleus and biological process this GO :0060896 and neural plate pattern specification and biological process this GO :0060914 and heart formation and biological process, this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0001701 and in utero embryonic development and biological process this GO :0001707 and mesoderm formation and biological process this GO :0001756 and somitogenesis and biological process this GO :0001880 and Mullerian duct regression and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0003007 and heart morphogenesis and biological process this GO :0003272 and endocardial cushion formation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006955 and immune response and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007389 and pattern specification process and biological process this GO :0007398 and ectoderm development and biological process this GO :0007399 and nervous system development and biological process this GO :0007492 and endoderm development and biological process this GO :0007507 and heart development and biological process this GO :0009950 and dorsal/ventral axis specification and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0009953 and dorsal/ventral pattern formation and biological process this GO :0010862 and positive regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0014032 and neural crest cell development and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702 : receptor signaling protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity, this GO :0004702 : receptor signaling protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0042803 : protein homodimerization activity, this GO :0046332 : SMAD binding, this GO :0046872 : metal ion binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042803 : protein homodimerization activity and also this GO :0046332 : SMAD binding and also this GO :0046872 : metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0019827 and stem cell maintenance and biological process this GO :0021983 and pituitary gland development and biological process this GO :0021998 and neural plate mediolateral regionalization and biological process this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030154 and cell differentiation and biological process this GO :0030324 and lung development and biological process this GO :0030425 and dendrite and cellular component this GO :0030501 and positive regulation of bone mineralization and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0035137 and hindlimb morphogenesis and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042733 and embryonic digit morphogenesis and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0045669 and positive regulation of osteoblast differentiation and biological process this GO :0045893 and positive regulation of transcription, type IA, 48514 and IDBG-631434 and ENSBTAG00000000231 and 404101, bone morphogenetic protein receptor |
| Identity: |
1076 |
| Gene: |
BMPR1A |
More about : BMPR1A |
| Long gene name: |
bone morphogenetic protein receptor type 1A |
| Synonyms gene: |
ACVRLK3 |
| Synonyms gene name: |
bone morphogenetic protein receptor, type IA |
| Synonyms: |
ALK3 CD292 |
| Locus: |
10q23, 2 |
| Discovery year: |
1994-12-12 |
| GenBank acession: |
BC028383 |
| Entrez gene record: |
657 |
| Pubmed identfication: |
8397373 9730621 |
| RefSeq identity: |
NM_004329 |
| Classification: |
Type 1 receptor serine/threonine kinases CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000018657 |
| Locus Specific Databases: |
LRG_298 |