| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TFEB |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the TFEB antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This TFEB antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P19484 |
| Purity: |
Antigen affinity |
| Description: |
Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF, In association with TFE3, It thereby plays a central role in expression of lysosomal genes, Plays a role in the signal transduction processes required for normal vascularization of the placenta, Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, Specifically recognizes the gamma-E3 box, a subset of E-boxes, activates the expression of CD40L in T-cells, leading to activate their expression, present in the heavy-chain immunoglobulin enhancer, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity, Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5') |
| Immunogen: |
A portion of amino acids 271-300 from the human protein was used as the immunogen for this TFEB antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the TFEB antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TFEB |
| Short name: |
TFEB Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TFEB (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11753 |
| Gene: |
TFEB |
More about : TFEB |
| Long gene name: |
transcription factor EB |
| Synonyms: |
TCFEB bHLHe35 |
| Locus: |
6p21, 1 |
| Discovery year: |
1999-09-20 |
| GenBank acession: |
M33782 |
| Entrez gene record: |
7942 |
| Pubmed identfication: |
2115126 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000014684 |