| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SOCS4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IF, WB, IHC |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the SOCS4 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SOCS4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q8WXH5 |
| Purity: |
Antigen affinity |
| Description: |
Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR, Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, [UniProt], SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction |
| Immunogen: |
A portion of amino acids 227-254 from the human protein was used as the immunogen for this SOCS4 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SOCS4 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SOCS4 |
| Short name: |
SOCS4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
suppressor on cytokine signaling 4 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
SOCS4 and IDBG-646714 and ENSBTAG00000021988 and 540412, SOCS4 and IDBG-7209 and ENSG00000180008 and 122809, Socs4 and IDBG-154333 and ENSMUSG00000048379 and 67296, multiple, this GO :0007175 and negative regulation of epidermal growth factor-activated receptor activity and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0032436 and positive regulation of proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0040008 and regulation of growth and biological process, suppressor of cytokine signaling 4 |
| Identity: |
19392 |
| Gene: |
SOCS4 |
More about : SOCS4 |
| Long gene name: |
suppressor of cytokine signaling 4 |
| Synonyms gene: |
SOCS7 |
| Synonyms gene name: |
suppressor of cytokine signaling 7 |
| Locus: |
14q22, 3 |
| Discovery year: |
2002-11-11 |
| GenBank acession: |
AF424815 |
| Entrez gene record: |
122809 |
| Pubmed identfication: |
12076535 10500304 |
| Classification: |
Suppressors of cytokine signaling SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000140311 |