| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
MSH2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB, IF |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the MSH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This MSH2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P43246 |
| Purity: |
Antigen affinity |
| Description: |
When cloned, [provided by RefSeq], coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC, it was discovered to be a human homolog of the E, MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) |
| Immunogen: |
A portion of amino acids 637-665 from the human protein was used as the immunogen for this MSH2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the MSH2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
MSH2 |
| Short name: |
MSH2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
coli) (Antibody to), colon cancer, nonpolyposis type 1 (E, mutS homolog 2 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ADP binding, COCA1 and FCC1 and HNPCC and HNPCC1 and LCFS2, MSH2 and IDBG-50900 and ENSG00000095002 and 4436, MSH2 and IDBG-633627 and ENSBTAG00000002742 and 533115, Msh2 and IDBG-201483 and ENSMUSG00000024151 and 17685, coli), colon cancer, nonpolyposis type 1 (E, nuclei, this GO :0000228 and nuclear chromosome and cellular component this GO :0000287 and magnesium ion binding and molecular function this GO :0000400 and four-way junction DNA binding and molecular function this GO :0000403 and Y-form DNA binding and molecular function this GO :0000404 and heteroduplex DNA loop binding and molecular function this GO :0000406 and double-strand/single-strand DNA junction binding and molecular function this GO :0000710 and meiotic mismatch repair and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0002204 and somatic recombination of immunoglobulin genes involved in immune response and biological process this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003697 and single-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006119 and oxidative phosphorylation and biological process this GO :0006200 and ATP catabolic process and biological process this GO :0006281 and DNA repair and biological process this GO :0006298 and mismatch repair and biological process this GO :0006301 and postreplication repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006311 and meiotic gene conversion and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007281 and germ cell development and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008094 and DNA-dependent ATPase activity and molecular function this GO :0008340 and determination of adult lifespan and biological process this GO :0008584 and male this GO nad development and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0010165 and response to X-ray and biological process this GO :0010224 and response to UV-B and biological process this GO :0016020 and membrane and cellular component this GO :0016446 and somatic hypermutation of immunoglobulin genes and biological process this GO :0016447 and somatic recombination of immunoglobulin gene segments and biological process this GO :0016887 and ATPase activity and molecular function this GO :0019237 and centromeric DNA binding and molecular function this GO :0019724 and B cell mediated immunity and biological process this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030183 and B cell differentiation and biological process this GO :0030983 and mismatched DNA binding and molecular function this GO :0031573 and intra-S DNA damage checkpoint and biological process this GO :0032137 and guanine/thymine mispair binding and molecular function this GO :0032139 and dinucleotide insertion or deletion binding and molecular function this GO :0032142 and single guanine insertion binding and molecular function this GO :0032143 and single thymine insertion binding and molecular function this GO :0032181 and dinucleotide repeat insertion binding and molecular function this GO :0032301 and MutSalpha complex and cellular component this GO :0032302 and MutSbeta complex and cellular component this GO :0032357 and oxidized purine DNA binding and molecular function this GO :0032405 and MutLalpha complex binding and molecular function this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043531 and ADP binding and molecular function this GO :0043570 and maintenance of DNA repeat elements and biological process this GO :0045128 and negative regulation of reciprocal meiotic recombination and biological process this GO :0045190 and isotype switching and biological process this GO :0045910 and negative regulation of DNA recombination and biological process this GO :0051096 and positive regulation of helicase activity and biological process, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0000400 : four-way junction DNA binding and also this GO :0000403 : Y-form DNA binding and also this GO :0000404 : heteroduplex DNA loop binding and also this GO :0000406 : double-strand/single-strand DNA junction binding and also this GO :0003677 : DNA binding and also this GO :0003684 : damaged DNA binding and also this GO :0003690 : double-stranded DNA binding and also this GO :0003697 : single-stranded DNA binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0008094 : DNA-dependent ATPase activity and also this GO :0016887 : ATPase activity and also this GO :0019237 : centromeric DNA binding and also this GO :0019899 : enzyme binding and also this GO :0019901 : protein kinase binding and also this GO :0030983 : mismatched DNA binding and also this GO :0032137 : guanine/thymine mispair binding and also this GO :0032139 : dinucleotide insertion or deletion binding and also this GO :0032142 : single guanine insertion binding and also this GO :0032143 : single thymine insertion binding and also this GO :0032181 : dinucleotide repeat insertion binding and also this GO :0032357 : oxidized purine DNA binding and also this GO :0032405 : MutLalpha complex binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043531 : ADP binding, this GO :0000400 : four-way junction DNA binding, this GO :0000403 : Y-form DNA binding, this GO :0000404 : heteroduplex DNA loop binding, this GO :0000406 : double-strand/single-strand DNA junction binding, this GO :0003677 : DNA binding, this GO :0003684 : damaged DNA binding, this GO :0003690 : double-stranded DNA binding, this GO :0003697 : single-stranded DNA binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0008094 : DNA-dependent ATPase activity, this GO :0016887 : ATPase activity, this GO :0019237 : centromeric DNA binding, this GO :0019899 : enzyme binding, this GO :0019901 : protein kinase binding, this GO :0030983 : mismatched DNA binding, this GO :0032137 : guanine/thymine mispair binding, this GO :0032139 : dinucleotide insertion or deletion binding, this GO :0032142 : single guanine insertion binding, this GO :0032143 : single thymine insertion binding, this GO :0032181 : dinucleotide repeat insertion binding, this GO :0032357 : oxidized purine DNA binding, this GO :0032405 : MutLalpha complex binding, this GO :0042803 : protein homodimerization activity, this GO :0043531 : ADP binding, mutS homolog 2 |
| Identity: |
7325 |
| Gene: |
MSH2 |
More about : MSH2 |
| Long gene name: |
mutS homolog 2 |
| Synonyms gene: |
COCA1 |
| Synonyms gene name: |
coli) , coli) homolog 2 (colon cancer, colon cancer, mutS (E, nonpolyposis type 1 (E, nonpolyposis type 1) mutS homolog 2 |
| Synonyms: |
HNPCC HNPCC1 |
| Locus: |
2p21-p16, 3 |
| Discovery year: |
1993-07-28 |
| GenBank acession: |
U03911 |
| Entrez gene record: |
4436 |
| Pubmed identfication: |
8484120 9843200 |
| Classification: |
MutS homologs |
| Havana BLAST/BLAT: |
OTTHUMG00000128861 |
| Locus Specific Databases: |
HNPCC Colon cancer gene variant databases MSH2 database at LOVD-China LOVD - Leiden Open Variation Database LRG_218 , Hereditary Non-Polyposis Colorectal Cancer |