HDAC4 Antibody

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Catalog number: F41149-0.08ML
Price: 199 €
Supplier: NJS poly
Product name: HDAC4 Antibody
Quantity: 0.08 ml
Other quantities: 0.08 ml 199€ 0.1ml 263€ 0.4 ml 406€ 1 vial 591€ 1 x 1 vial 486€ 100ug 370€ 100ul 486€ 50ug 299€
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Category: Antibody
Concentration: pH 7, with 0, 09% sodium azide, 4, In 1X PBS
Form: Purified
Conjugation: Unconjugated
Clone: Polyclonal antibody
Recognised antigen: HDAC4
Host animal: Rabbit (Oryctolagus cuniculus)
Clonality: Polyclonal (rabbit origin)
Species reactivity: Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications: ELISA, WB
Recommended dilutions: Western blot: 1:1000
Notes: Titration of the HDAC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented use: This HDAC4 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #: P56524
Purity: Purified
Description: Acetylation of lysine residues induces conformational changes in core histones by destabilizing nucleosomes and allowing transcription factors access to recognition elements in DNA, Binding of calmodulin to HDAC4 leads to its dissociation from MEF2, Binding of the N terminus of HDAC4 to MEF2C represses MEF2C transcription activity, Chromatin can become alternatively revealed to or concealed from transcription factors, Deacetylation of histones by histone deacetylases (HDACs) reseals the chromosomal package, Experimental conditions leading to the suppression of HDAC4 binding to NCOR2 and to HDAC3 result in loss of enzymatic activity associated with HDAC4, HDAC4, HDAC4, HDAC4 and MITR contain calmodulin-binding domains that overlap with their MEF2 binding domains, HDAC4 does not bind DNA directly, In murine studies, MITR, The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2, Together, a higher-order structure, a transcription factor necessary for chondrocyte hypertrophy, and CABIN1 constitute a family of calcium-sensitive transcriptional repressors of MEF2, but rather through MEF2C and MEF2D, establishing HDAC4 as a central regulator of chondrocyte hypertrophy and skeletogenesis, indicating regulation of transcription by bridging the enzymatically active NCOR2-HDAC3 complex and select transcription factors, interacts with and inhibits the activity of Runx2 in mice, leading to a repression of transcription, relieving MEF2 from the transcriptional repression by HDAC4, which is expressed in prehypertrophic chondrocytes, DNA is wrapped around histone proteins to form nucleosomes and chromatin fiber
Immunogen: A portion of amino acids 1052-1084 from the human protein was used as the immunogen for this HDAC4 antibody
Storage: Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HDAC4 antibody and store frozen at -20 deg
Properties: C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target: HDAC4
Short name: HDAC4 Antibody
Technique: antibodies against human proteins, antibodies for, Antibody
Alternative name: histone deacetylase 4 (Antibody to)
Alternative technique: antibodies
Alternative to gene target: AHO3 and BDMR and HA6116 and HD4 and HDAC-4 and HDAC-A and HDACA, DNA-templated and biological process this GO :0006954 and inflammatory response and biological process this GO :0007399 and nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010832 and negative regulation of myotube differentiation and biological process this GO :0010882 and regulation of cardiac muscle contraction by calcium ion signaling and biological process this GO :0014894 and response to denervation involved in regulation of muscle adaptation and biological process this GO :0014898 and cardiac muscle hypertrophy in response to stress and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0017053 and transcriptional repressor complex and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030017 and sarcomere and cellular component this GO :0030018 and Z disc and cellular component this GO :0030183 and B cell differentiation and biological process this GO :0030955 and potassium ion binding and molecular function this GO :0031594 and neuromuscular junction and cellular component this GO :0031672 and A band and cellular component this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0033235 and positive regulation of protein sumoylation and biological process this GO :0033558 and protein deacetylase activity and molecular function this GO :0033613 and activating transcription factor binding and molecular function this GO :0034983 and peptidyl-lysine deacetylation and biological process this GO :0042113 and B cell activation and biological process this GO :0042493 and response to drug and biological process this GO :0042641 and actomyosin and cellular component this GO :0042826 and histone deacetylase binding and molecular function this GO :0043234 and protein complex and cellular component this GO :0043393 and regulation of protein binding and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045820 and negative regulation of glycolytic process and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048742 and regulation of skeletal muscle fiber development and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051153 and regulation of striated muscle cell differentiation and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070555 and response to interleukin-1 and biological process this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, HDAC4 and IDBG-642244 and ENSBTAG00000017764 and 517559, HDAC4 and IDBG-84594 and ENSG00000068024 and 9759, Hdac4 and IDBG-181579 and ENSMUSG00000026313 and 208727, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001047 and core promoter binding and molecular function this GO :0001501 and skeletal system development and biological process this GO :0002076 and osteoblast development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006338 and chromatin remodeling and biological process this GO :0006351 and transcription, this GO :0001047 : core promoter binding, this GO :0001047 : core promoter binding and also this GO :0003677 : DNA binding and also this GO :0003714 : transcription corepressor activity and also this GO :0004407 : histone deacetylase activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0008270 : zinc ion binding and also this GO :0019901 : protein kinase binding and also this GO :0030955 : potassium ion binding and also this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033558 : protein deacetylase activity and also this GO :0033613 : activating transcription factor binding and also this GO :0042826 : histone deacetylase binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491 : repressing transcription factor binding and also this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003677 : DNA binding, this GO :0003714 : transcription corepressor activity, this GO :0004407 : histone deacetylase activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0008270 : zinc ion binding, this GO :0019901 : protein kinase binding, this GO :0030955 : potassium ion binding, this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0033558 : protein deacetylase activity, this GO :0033613 : activating transcription factor binding, this GO :0042826 : histone deacetylase binding, this GO :0043565 : sequence-specific DNA binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0070491 : repressing transcription factor binding, this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 4
Identity: 14063
Gene: HDAC4 | More about : HDAC4
Long gene name: histone deacetylase 4
Synonyms gene: BDMR
Synonyms gene name: brachydactyly-mental retardation syndrome
Synonyms: KIAA0288 HDAC-A HDACA HD4 HA6116 HDAC-4
Locus: 2q37, 3
Discovery year: 2000-11-28
GenBank acession: AB006626
Entrez gene record: 9759
Pubmed identfication: 10206986 10220385 20691407
RefSeq identity: NM_006037
Classification: Histone deacetylases, class IIA
Havana BLAST/BLAT: OTTHUMG00000133344

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