| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CD31 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Hamster , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the CD31 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This CD31 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q08481 |
| Purity: |
Antigen affinity |
| Description: |
During apoptosis, Induces susceptibility to atherosclerosis, Modulates BDKRB2 activation (By similarity), Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore, thus triggering the process of engulfment), Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions |
| Immunogen: |
A portion of amino acids 508-536 from the mouse protein was used as the immunogen for this CD31 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CD31 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CD31 |
| Short name: |
CD31 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CD31 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8823 |
| Gene: |
PECAM1 |
More about : PECAM1 |
| Long gene name: |
platelet and endothelial cell adhesion molecule 1 |
| Synonyms gene name: |
platelet/endothelial cell adhesion molecule 1 |
| Synonyms: |
CD31 |
| Synonyms name: |
CD31 antigen |
| Locus: |
17q23, 3 |
| Discovery year: |
1995-11-29 |
| GenBank acession: |
L34631 M37780 |
| Entrez gene record: |
5175 |
| Pubmed identfication: |
8661055 1690453 |
| RefSeq identity: |
NM_000442 |
| Classification: |
CD molecules Immunoglobulin like domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000175829 |