| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CXCR3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IHC, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the CXCR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This CXCR3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P49682 |
| Purity: |
Antigen affinity |
| Description: |
As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface, IP10, IP10, In addition, Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein, Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant), Mig and I-TAC are commonly produced by local cells in inflammatory lesion, Mig and I-TAC belong to the structural subfamily of CXC chemokines, Multiple transcript variants encoding different isoforms have been found for this gene, Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors, Therefore, This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues, cellular responses are typically rapid and short in duration, cytoskeletal changes and chemotactic migration, in which a single amino acid residue separates the first two of four highly conserved Cys residues, most notably integrin activation, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells, termed IP10 (interferon-g-inducible 10 kDa protein), this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases, This gene encodes a G protein-coupled receptor with selectivity for three chemokines |
| Immunogen: |
A portion of amino acids 140-167 from the human protein was used as the immunogen for this CXCR3 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CXCR3 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CXCR3 |
| Short name: |
CXCR3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
chemokine (C-X-C motif) receptor 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C-X-C chemokine binding, CD182 and CD183 and CKR-L2 and CMKAR3 and GPR9 and IP10-R and Mig-R and MigR, CXCR3 and IDBG-635748 and ENSBTAG00000014798 and 497018, CXCR3 and IDBG-76333 and ENSG00000186810 and 2833, Cell surfaces, Cxcr3 and IDBG-164788 and ENSMUSG00000050232 and 12766, this GO :0001525 and angiogenesis and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0002685 and regulation of leukocyte migration and biological process this GO :0004872 and receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006928 and cellular component movement and biological process this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010818 and T cell chemotaxis and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0019722 and calcium-mediated signaling and biological process this GO :0019956 and chemokine binding and molecular function this GO :0019958 and C-X-C chemokine binding and molecular function this GO :0030816 and positive regulation of cAMP metabolic process and biological process this GO :0043950 and positive regulation of cAMP-mediated signaling and biological process this GO :0045087 and innate immune response and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050921 and positive regulation of chemotaxis and biological process this GO :0051281 and positive regulation of release of sequestered calcium ion into cytosol and biological process this GO :0071954 and chemokine (C-C motif) ligand 11 production and biological process this GO :1900118 and negative regulation of execution phase of apoptosis and biological process this GO :1900119 and positive regulation of execution phase of apoptosis and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0016494 : C-X-C chemokine receptor activity and also this GO :0019956 : chemokine binding and also this GO :0019958 : C-X-C chemokine binding, this GO :0004930 : G-protein coupled receptor activity, this GO :0004950 : chemokine receptor activity, this GO :0016494 : C-X-C chemokine receptor activity, this GO :0019956 : chemokine binding, this GO :0019958 : C-X-C chemokine binding, chemokine (C-X-C motif) receptor 3 |
| Identity: |
4540 |
| Gene: |
CXCR3 |
More about : CXCR3 |
| Long gene name: |
C-X-C motif chemokine receptor 3 |
| Synonyms gene: |
GPR9 |
| Synonyms gene name: |
G protein-coupled receptor 9 chemokine (C-X-C motif) receptor 3 |
| Synonyms: |
CKR-L2 CMKAR3 IP10-R MigR CD183 |
| Locus: |
Xq13, 1 |
| Discovery year: |
1994-11-01 |
| GenBank acession: |
U32674 |
| Entrez gene record: |
2833 |
| Pubmed identfication: |
8666380 9064356 |
| Classification: |
CD molecules C-X-C motif chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000033326 |