PKR Antibody

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Catalog number: F40174-0.4ML
Price: 406 €
Supplier: NJS poly
Product name: PKR Antibody
Quantity: 0.4 ml
Other quantities: 100ug 431€
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Category: Antibody
Concentration: pH 7, with 0, 09% sodium azide, 4, In 1X PBS
Form: Purified
Conjugation: Unconjugated
Clone: Polyclonal antibody
Recognised antigen: PKR
Host animal: Rabbit (Oryctolagus cuniculus)
Clonality: Polyclonal (rabbit origin)
Species reactivity: Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications: ELISA, IHC, WB
Recommended dilutions: IHC (Paraffin): 1:50-1:100, Western blot: 1:1000
Notes: Titration of the PKR antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented use: This PKR antibodyis to be used only for research purposes and not for diagnostics
Uniprot #: P19525
Purity: Purified
Description: Activation by dsRNAs leads to autophosphorylation of PKR and allows the kinase to phosphorylate its natural substrate, Apoptosis induced by live pathogenic gram-positive and gram-negative bacteria requirs both TLR4 and PKR, PRKR, activates IKK and NFKB, double-stranded RNA-activated protein kinase (PRKR/PKR) is a serine-threonine kinase, leading to the inhibition of protein synthesis, possibly representing a major mechanism for pathogenic bacteria that use specific virulence factors to avoid detection and destruction by the innate immune system, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha), thereby suppressing apoptosis, which is involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, Interferon-induced
Immunogen: A portion of amino acids 11-42 from the human protein was used as the immunogen for this PKR antibody
Storage: Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PKR antibody and store frozen at -20 deg
Properties: C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target: PKR
Short name: PKR Antibody
Technique: antibodies against human proteins, antibodies for, Antibody
Alternative name: PKR (Antibody to)
Alternative technique: antibodies
Identity: 9437
Gene: EIF2AK2 | More about : EIF2AK2
Long gene name: eukaryotic translation initiation factor 2 alpha kinase 2
Synonyms gene: PRKR
Synonyms gene name: interferon-inducible double stranded RNA dependent , protein kinase
Synonyms: PKR EIF2AK1 PPP1R83
Synonyms name: protein phosphatase 1, regulatory subunit 83
Locus: 2p22, 2
Discovery year: 1992-12-04
GenBank acession: BC057805
Entrez gene record: 5610
Pubmed identfication: 1351683
RefSeq identity: NM_002759
Classification: Protein phosphatase 1 regulatory subunits
Havana BLAST/BLAT: OTTHUMG00000100962

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