| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CD117 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the CD117 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This CD117 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P10721 |
| Purity: |
Antigen affinity |
| Description: |
Altered forms of this receptor may be associated with some types of cancer, It is a receptor tyrosine kinase type III, Signalling through CD117 plays a role in cell survival, When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, [Wiki], also known as steel factor or c-kit ligand, and differentiation, proliferation, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell, which binds to stem cell factor (a substance that causes certain types of cells to grow), CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types |
| Immunogen: |
A portion of amino acids 680-711 from the human protein was used as the immunogen for this CD117 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CD117 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CD117 |
| Short name: |
CD117 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CD117 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6342 |
| Gene: |
KIT |
More about : KIT |
| Long gene name: |
KIT proto-oncogene receptor tyrosine kinase |
| Synonyms gene: |
PBT |
| Synonyms gene name: |
piebald trait v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| Synonyms: |
CD117 SCFR C-Kit |
| Locus: |
4q12 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
S67773 |
| Entrez gene record: |
3815 |
| Pubmed identfication: |
9027509 |
| RefSeq identity: |
NM_000222 |
| Classification: |
CD molecules Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000128713 |
| Locus Specific Databases: |
LRG_307 |