| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
MARK1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the MARK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This MARK1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9P0L2 |
| Purity: |
Purified |
| Description: |
APP vesicles, Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, In primary retinal ganglion cells, This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged, This transport inhibition can be rescued by phosphorylating tau with MARK, and other cell components which leads to starvation of axons and vulnerability against stress, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles, transfection with tau leads to the inhibition of axonal transport of mitochondria, MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration |
| Immunogen: |
A portion of amino acids 671-700 from the human protein was used as the immunogen for this MARK1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the MARK1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
MARK1 |
| Short name: |
MARK1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
mitogen-stimulated protein kinase/microtubule affinity-regulating kinase 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
MARK and Par-1c and Par1c, MARK1 and IDBG-106753 and ENSG00000116141 and 4139, Mark1 and IDBG-207919 and ENSMUSG00000026620 and 226778, Plasma membranes, phosphatidylinositol-4, this GO :0000226 and microtubule cytoskeleton organization and biological process this GO :0000287 and magnesium ion binding and molecular function this GO :0001764 and neuron migration and biological process this GO :0001786 and phosphatidylserine binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005546 and phosphatidylinositol-4, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0001786 : phosphatidylserine binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0005546 : phosphatidylinositol-4, this GO :0001786 : phosphatidylserine binding, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0005546 : phosphatidylinositol-4, this GO :0016772 : transferase activity, this GO :0050321 : tau-protein kinase activity, this GO :0070300 : phosphatidic acid binding, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0050321 : tau-protein kinase activity and also this GO :0070300 : phosphatidic acid binding, transferring phosphorus-containing groups and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0050321 and tau-protein kinase activity and molecular function this GO :0070300 and phosphatidic acid binding and molecular function, 5-bisphosphate binding, 5-bisphosphate binding and also this GO :0016772 : transferase activity, 5-bisphosphate binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007010 and cytoskeleton organization and biological process this GO :0015630 and microtubule cytoskeleton and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0016772 and transferase activity, MAP/microtubule affinity-regulating kinase 1 |
| Identity: |
6896 |
| Gene: |
MARK1 |
More about : MARK1 |
| Long gene name: |
microtubule affinity regulating kinase 1 |
| Synonyms gene name: |
MAP/microtubule affinity-regulating kinase 1 |
| Synonyms: |
MARK PAR-1C |
| Locus: |
1q41 |
| Discovery year: |
1997-10-27 |
| GenBank acession: |
AF154845 |
| Entrez gene record: |
4139 |
| Pubmed identfication: |
9108484 |
| Havana BLAST/BLAT: |
OTTHUMG00000037351 |