| Gene info: |
Following type I IFN (IFN-a, ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, In response to type II IFN (IFN-&, It then forms a homodimer termed IFN-&, Jak kinases (TYK2 and JAK1) are activated, STAT1 is tyrosine- and serine-phosphorylated, The phosphorylated STATs dimerize, activated sequence (GAS) to drive the expression of the target genes, and IFN-&, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, inducing a cellular antiviral state, leading to tyrosine phosphorylation of STAT1 and STAT2, migrates into the nucleus and binds to the IFN &, that enters the nucleus, which drive the cell in an antiviral state, #946, #947, #947, #947, <, ), ) binding to cell surface receptors, -activated factor (GAF), /b>, : Signal transducer and activator of transcription that mediates signaling by interferons (IFNs), FUNCTION<, b> |
| Gene names: |
Transcription factor ISGF-3 components p91/p84, Signal transducer and activator of transcription 1alpha/b |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Immunoaffinity Purified |
| Ab raised in: |
Chicken |
| Type: |
Polyclonal |
| Antigen: |
51-235 |
| Immuno application: |
Western Blot |
| Antibody advice: |
antibody can be used for the detection of Signal transducer and activator of transcription 1-a, by Western Blot, #946, #946, /&, /&, Signal transducer and activator of transcription 1-a |
| Suspention, pH, azide: |
No preservatives added, Phosphate-Buffered Saline |
| Keep at: |
Antibodies should not be exposed to prolonged high temperatures, As with all antibodies care should be taken to avoid repeated freeze thaw cycles, Long term storage should be at -20 grades C, STAT1 antibody can be stored at 4 grades C for short term (weeks) |
| Works with: |
Human |
| Omim nr: |
21536301 |
| Ncbi nr: |
1, NP_644671 |
| KDa: |
3 kDa (calculated), 87 |
| Vial with antibody: |
in solution |
| Quantity per ml: |
1 mg/mL |
| NCBI GENE nr: |
6772 |
| GENE symbol: |
STAT1 |
| Antigene name: |
91kDa, signal transducer and activator of transcription 1 |
| Source: |
Homo sapiens |
| Protein nr: |
P42224 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
STAT1 |
| Short name: |
anti-STAT1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
91kDa (Antibody to), antibody to-signal transducer and activator on transcription 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
91kDa, CANDF7 and IMD31A and IMD31B and IMD31C and ISGF-3 and STAT91, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0007584 and response to nutrient and biological process this GO :0008015 and blood circulation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0009617 and response to bacterium and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016032 and viral process and biological process this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019899 and enzyme binding and molecular function this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031663 and lipopolysaccharide-mediated signaling pathway and biological process this GO :0031730 and CCR5 chemokine receptor binding and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0033209 and tumor necrosis factor-mediated signaling pathway and biological process this GO :0034097 and response to cytokine and biological process this GO :0034240 and negative regulation of macrophage fusion and biological process this GO :0035458 and cellular response to interferon-beta and biological process this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043124 and negative regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043330 and response to exogenous dsRNA and biological process this GO :0043434 and response to peptide hormone and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0051591 and response to cAMP and biological process this GO :0051607 and defense response to virus and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0061326 and renal tubule development and biological process this GO :0072136 and metanephric mesenchymal cell proliferation involved in metanephros development and biological process this GO :0072162 and metanephric mesenchymal cell differentiation and biological process this GO :0072308 and negative regulation of metanephric nephron tubule epithelial cell differentiation and biological process, STAT1 and IDBG-642654 and ENSBTAG00000007867 and 510814, STAT1 and IDBG-77617 and ENSG00000115415 and 6772, Stat1 and IDBG-153162 and ENSMUSG00000026104 and 20846, nuclei, sequence-specific DNA binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0000979 and RNA polymerase II core promoter sequence-specific DNA binding and molecular function this GO :0000983 and RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity and molecular function this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0003340 and negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis and biological process this GO :0003677 and DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding and also this GO :0000983 : RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003690 : double-stranded DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0004871 : signal transducer activity and also this GO :0005164 : tumor necrosis factor receptor binding and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0019899 : enzyme binding and also this GO :0031730 : CCR5 chemokine receptor binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043565 : sequence-specific DNA binding, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding, this GO :0000983 : RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, this GO :0003677 : DNA binding, this GO :0003690 : double-stranded DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0004871 : signal transducer activity, this GO :0005164 : tumor necrosis factor receptor binding, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0019899 : enzyme binding, this GO :0031730 : CCR5 chemokine receptor binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043565 : sequence-specific DNA binding, 515988, signal transducer and activator of transcription 1 |
| Identity: |
11362 |
| Gene: |
STAT1 |
More about : STAT1 |
| Long gene name: |
signal transducer and activator of transcription 1 |
| Synonyms gene name: |
91kD signal transducer and activator of transcription 1, 91kDa , signal transducer and activator of transcription 1 |
| Synonyms: |
STAT91 ISGF-3 |
| Synonyms name: |
transcription factor ISGF-3 components p91/p84 |
| Locus: |
2q32, 2 |
| Discovery year: |
1995-11-08 |
| Entrez gene record: |
6772 |
| Pubmed identfication: |
7885841 |
| RefSeq identity: |
NM_007315 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000132699 |
| Locus Specific Databases: |
STAT1base: Mutation registry for STAT1 deficiency LRG_111 |