| Gene info: |
<, Although the first symptom of HHT1 in children is generally nose bleed, HHT1 is an autosomal dominant multisystemic vascular dysplasia, May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors, all secondary manifestations of the underlying vascular dysplasia, also known as Rendu-Osler-Weber syndrome 1 (ORW1), and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations, characterized by recurrent epistaxis, gastro-intestinal hemorrhage, muco-cutaneous telangiectases, there is an important clinical heterogeneity, <, /b>, /b>, : Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300], : Major glycoprotein of vascular endothelium, DISEASE<, FUNCTION<, b>, b> |
| Gene names: |
CD105 antigen, END, Endoglin, HHT1, ORW1, END |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Immunoaffinity Purified |
| Ab raised in: |
Chicken |
| Type: |
Polyclonal |
| Antigen: |
341-470 |
| Immuno application: |
Western Blot |
| Antibody advice: |
Endoglin antibody can be used for the detection of Endoglin by Western Blot |
| Suspention, pH, azide: |
No preservatives added, Phosphate-Buffered Saline |
| Keep at: |
Antibodies should not be exposed to prolonged high temperatures, As with all antibodies care should be taken to avoid repeated freeze thaw cycles, Long term storage should be at -20 grades C, ENG antibody can be stored at 4 grades C for short term (weeks) |
| Works with: |
Human |
| Omim nr: |
4557555 |
| Ncbi nr: |
1, NP_000109 |
| KDa: |
6 kDa (calculated), 70 |
| Vial with antibody: |
in solution |
| Quantity per ml: |
1 mg/mL |
| NCBI GENE nr: |
2022 |
| GENE symbol: |
ENG |
| Antigene name: |
endoglin |
| Source: |
Homo sapiens |
| Protein nr: |
P17813 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
ENG |
| Short name: |
anti-ENG Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-endoglin (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0007155 and cell adhesion and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010628 and positive regulation of gene expression and biological process this GO :0010862 and positive regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0016477 and cell migration and biological process this GO :0017015 and regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0022009 and central nervous system vasculogenesis and biological process this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030155 and regulation of cell adhesion and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030513 and positive regulation of BMP signaling pathway and biological process this GO :0031953 and negative regulation of protein autophosphorylation and biological process this GO :0031960 and response to corticosteroid and biological process this GO :0032967 and positive regulation of collagen biosynthetic process and biological process this GO :0034713 and type I transforming growth factor beta receptor binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0036273 and response to statin and biological process this GO :0042060 and wound healing and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042325 and regulation of phosphorylation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048185 and activin binding and molecular function this GO :0048745 and smooth muscle tissue development and biological process this GO :0048844 and artery morphogenesis and biological process this GO :0048845 and venous blood vessel morphogenesis and biological process this GO :0048870 and cell motility and biological process this GO :0050431 and transforming growth factor beta binding and molecular function this GO :0051001 and negative regulation of nitric-oxide synthase activity and biological process this GO :0060326 and cell chemotaxis and biological process this GO :0060348 and bone development and biological process this GO :0060394 and negative regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0070022 and transforming growth factor beta receptor homodimeric complex and cellular component this GO :0070278 and extracellular matrix constituent secretion and biological process this GO :0070483 and detection of hypoxia and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071559 and response to transforming growth factor beta and biological process this GO :0072563 and endothelial microparticle and cellular component, END and HHT1 and ORW1, ENG and IDBG-639059 and ENSBTAG00000008997 and 615844, ENG and IDBG-86582 and ENSG00000106991 and 2022, Eng and IDBG-160783 and ENSMUSG00000026814 and 13805, cytoplasmic mediator activity, cytoplasmic mediator activity and also this GO :0005114 : type II transforming growth factor beta receptor binding and also this GO :0005515 : protein binding and also this GO :0005534 : galactose binding and also this GO :0005539 : glycosaminoglycan binding and also this GO :0034713 : type I transforming growth factor beta receptor binding and also this GO :0042803 : protein homodimerization activity and also this GO :0048185 : activin binding and also this GO :0050431 : transforming growth factor beta binding, cytoplasmic mediator activity and molecular function this GO :0005114 and type II transforming growth factor beta receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005534 and galactose binding and molecular function this GO :0005539 and glycosaminoglycan binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006355 and regulation of transcription, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001300 and chronological cell aging and biological process this GO :0001525 and angiogenesis and biological process this GO :0001569 and patterning of blood vessels and biological process this GO :0001570 and vasculogenesis and biological process this GO :0001666 and response to hypoxia and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0001947 and heart looping and biological process this GO :0003084 and positive regulation of systemic arterial blood pressure and biological process this GO :0003273 and cell migration involved in endocardial cushion formation and biological process this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005072 and transforming growth factor beta receptor, this GO :0004888 : transmembrane signaling receptor activity, this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005072 : transforming growth factor beta receptor, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005072 : transforming growth factor beta receptor, this GO :0005114 : type II transforming growth factor beta receptor binding, this GO :0005515 : protein binding, this GO :0005534 : galactose binding, this GO :0005539 : glycosaminoglycan binding, this GO :0034713 : type I transforming growth factor beta receptor binding, this GO :0042803 : protein homodimerization activity, this GO :0048185 : activin binding, this GO :0050431 : transforming growth factor beta binding, transforming growth factor beta receptor, endoglin |
| Identity: |
3349 |
| Gene: |
ENG |
More about : ENG |
| Long gene name: |
endoglin |
| Synonyms gene: |
ORW1 ORW |
| Synonyms gene name: |
Osler-Rendu-Weber syndrome 1 |
| Synonyms: |
END HHT1 CD105 |
| Locus: |
9q34, 11 |
| Discovery year: |
1993-03-03 |
| GenBank acession: |
AF035753 |
| Entrez gene record: |
2022 |
| Pubmed identfication: |
8404038 10548503 |
| Classification: |
CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000020723 |
| Locus Specific Databases: |
Hereditary Hemorrhagic Telangiectasia (HHT) Mutation Database LRG_589 |