| Gene info: |
Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C, Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane, In contrast activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase, They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse, When activated, The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system |
| Gene names: |
Gprc1e, Mglur5, mGluR5, mGlur5, mGluR5 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Affinity Purified |
| Ab raised in: |
Rabbit |
| Type: |
Polyclonal |
| Antigen: |
mGluR 5/1a polyclonal antibody was made against a peptide from the C-terminal region of mGluR5 and mGluR1a |
| Immuno application: |
immuno-histo-chemistry, Western Blot |
| Antibody advice: |
Applications include Dot Blots (DB), Immunohistochemistry (IHC) and Western Blots (WB), Immunolabeling blocked by preadsorption of antibody with the C-terminal peptide immunogen, Rabbit anti-mGluR 5/1a recognizes both mGluR5 and mGluR1a in rat brain, When internally tested under ideal conditions the working dilutions were 1:500 for IHC and 1:1000 for DB and WB, Metabotropic Glutamate Receptor 5/1a antibody allows for strong and specific immunolabeling of ~125k mGluR5 and mGluR1a and the ~250k mGluR5 and mGluR1a dimers in Western blots of rat brain at antibody dilution of 1:1000 |
| Suspention, pH, azide: |
100 ug per mL BSA and 50% glycerol, 150 mM NaCl, 100 uL in 10 mM HEPES (pH 7, 5) |
| Keep at: |
Stable for one year, but shorter term storage at &ndash, 20 grades C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol, 80 grades C is recommended, For long term storage &ndash |
| Works with: |
Rat |
| Omim nr: |
1170947 |
| Ncbi nr: |
P31424 |
| KDa: |
125/250 |
| Vial with antibody: |
in solution |
| NCBI GENE nr: |
24418 |
| GENE symbol: |
Grm5 |
| Antigene name: |
metabotropic 5, glutamate receptor |
| Source: |
Rattus norvegicus |
| Protein nr: |
P31424 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
Metabotropic Glutamate Receptor 5/1a |
| Short name: |
anti-Metabotropic Glutamate Receptor 5/1a Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-Metabotropic Glutamate Receptor 5/1a (Antibody to) |
| Alternative technique: |
antibodies |