| Gene info: |
GABAA-Rs are important therapeutic targets for a range of sedative, However, Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA, Lastly, The GABAA-R is a multimeric subunit complex, The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor, To date six alphas, and hypnotic agents and are implicated in several diseases including epilepsy, and substance abuse, anxiety, anxiolytic, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype, coexpression of a gamma subunit is required for benzodiazepine modulation, depression, four betas and four gammas, have been identified, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function, plus alternative splicing variants of some of these subunits, Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system |
| Gene names: |
Gabra-6 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Neat Serum |
| Ab raised in: |
Rabbit |
| Type: |
Polyclonal |
| Antigen: |
GABAA Receptor a6 polyclonal antibody was made against a peptide representing a sequence that is specific for the a6 subunit of the receptor |
| Immuno application: |
Western Blot |
| Antibody advice: |
Applications include Dot Blots (DB) and Western Blots (WB), Human, Peptide antigen has no homology with any other GABAA-R subunit, When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB, and rat have 100% amino acid sequence identity with the antigen used to raise the antibody, mouse, GABAA Receptor antibody recognizes 57k band in Western blots of rat brain |
| Keep at: |
GABA A Receptor alpha 6 antibody can be stored at -20 grades C and is stable at -20 grades C for at least 1 year |
| Works with: |
Rat, Human |
| Omim nr: |
232127 |
| Ncbi nr: |
P30191 |
| KDa: |
57 |
| Vial with antibody: |
in solution |
| NCBI GENE nr: |
29708 |
| GENE symbol: |
Gabra6 |
| Antigene name: |
alpha 6, gamma-aminobutyric acid (GABA) A receptor |
| Source: |
Rattus norvegicus |
| Protein nr: |
P30191 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
GABA A Receptor alpha 6 |
| Short name: |
anti-GABA A Receptor alpha 6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-GABA A Receptor a 6 (Antibody to) |
| Alternative technique: |
antibodies |