| Gene info: |
Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase, Conversely there also appears to be a feedback phosphorylation of MEK 1 by MAP kinase, The sites on MEK 1 that are phosphorylated by MAP kinase are Thr292 and Thr386, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation and this pathway also plays a key role in synaptic plasticity in brain, MEK 1 (MAP Kinase Kinase |
| Gene names: |
ERK activator kinase 1, MAP kinase kinase 1, MAPKK1, MEK1, MKK1, PRKMK1, CFC3 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Affinity Purified |
| Ab raised in: |
Rabbit |
| Type: |
Polyclonal |
| Spicific to: |
MEK1 antibody is specific for the 45k MEK 1 phosphorylated at Thr292 |
| Antigen: |
MEK 1 (Thr292) polyclonal antibody was made against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho Thr292 of human MEK 1 |
| Immuno application: |
Western Blot |
| Antibody advice: |
Suitability for Immunohistochemistry (IHC) has not yet been determined, When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB, Applications include Dot Blots (DB) and Western Blots (WB) |
| Suspention, pH, azide: |
100 ug per mL BSA and 50% glycerol, 150 mM NaCl, 100 uL in 10 mM HEPES (pH 7, 5) |
| Keep at: |
Stable for one year, but shorter term storage at &ndash, 20 grades C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol, 80 grades C is recommended, For long term storage &ndash |
| Works with: |
Rat |
| Omim nr: |
400274 |
| Ncbi nr: |
Q02750 |
| KDa: |
45 |
| Vial with antibody: |
in solution |
| NCBI GENE nr: |
5604 |
| GENE symbol: |
MAP2K1 |
| Antigene name: |
mitogen-activated protein kinase kinase 1 |
| Source: |
Homo sapiens |
| Protein nr: |
Q02750 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
MEK1 (phospho Thr292) |
| Short name: |
anti-MEK1 (phospho Thr292) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-MEK1 (phosphorilated Thr292) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6840 |
| Gene: |
MAP2K1 |
More about : MAP2K1 |
| Long gene name: |
mitogen-activated protein kinase kinase 1 |
| Synonyms gene: |
PRKMK1 |
| Synonyms: |
MEK1 MAPKK1 |
| Locus: |
15q22, 31 |
| Discovery year: |
1993-11-05 |
| GenBank acession: |
L11284 |
| Entrez gene record: |
5604 |
| Pubmed identfication: |
9465908 8388392 |
| Classification: |
Mitogen-activated protein kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000133196 |
| Locus Specific Databases: |
The Globin Gene Server LRG_725 |