| Gene info: |
2002) recently demonstrated that the functional coupling of GABA (B) R1/GABA (B) R2 receptors to inwardly rectifying K+ channels rapidly desensitizes, 2003), GABAB receptors are heterodimeris G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system, In addition to its postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, Moss and colleagues (Couve, There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors, This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cytoplasmic tail of GABA (B) R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA), et al, Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system |
| Gene names: |
G-protein coupled receptor 51, GABA-B receptor 2, Gpr51, Gpr51 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Affinity Purified |
| Ab raised in: |
Rabbit |
| Type: |
Polyclonal |
| Spicific to: |
GABA B Receptor antibody is specific for Mr 110k GABAB R2 Subunit phosphorylated at Ser892 in rat brain membrane fractions |
| Antigen: |
GABAB (Ser892) polyclonal antibody was made against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho-Ser892 of the GABAB Receptor R2 Subunit |
| Immuno application: |
Western Blot |
| Antibody advice: |
Suitability for Immunohistochemistry (IHC) has not yet been determined, When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB, Applications include Dot Blots (DB) and Western Blots (WB) |
| Suspention, pH, azide: |
100 ug per mL BSA and 50% glycerol, 150 mM NaCl, 100 uL in 10 mM HEPES (pH 7, 5) |
| Keep at: |
Stock solutions are stable for a minimum of 1 year at -20 grades C, but shorter term storage at -20 grades C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol, For long term storage -80 grades C is recommended |
| Works with: |
Mouse, Rat, Human |
| Omim nr: |
12643481 |
| Ncbi nr: |
O88871 |
| KDa: |
110 |
| Vial with antibody: |
in solution |
| NCBI GENE nr: |
83633 |
| GENE symbol: |
Gabbr2 |
| Antigene name: |
gamma-aminobutyric acid (GABA) B receptor 2 |
| Source: |
Rattus norvegicus |
| Protein nr: |
O88871 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
GABA B Receptor (phospho Ser892) |
| Short name: |
anti-GABA B Receptor (phospho Ser892) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-GABA B Receptor (phosphorilated Ser892) (Antibody to) |
| Alternative technique: |
antibodies |