| Gene info: |
All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level, BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, BDNF is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells, BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, In addition, NT3, and NT4, and retinal ganglial cells, basal forebrain cholinergic neurons, dopaminergic neurons in the substantia nigra, functional studies showed that age-associated changes in BDNF-mediated pathways can enhance inflammation and increase myocardial injury after myocardial infarction in the aging heart, hippocampal neurons, including neural crest and placode derived sensory neurons, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non neuronal cells, Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF |
| Gene names: |
Abrineurin, BDNF, BULN2Brain-derived neurotrophic factor, ANON2 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Anti-hBDNF specific antibody was purified by affinity chromatography employing immobilized hBDNF matrix |
| Ab raised in: |
Rabbit |
| Type: |
Polyclonal |
| Antigen: |
98%) recombinant hBDNF (human Brain-Derived Neurotrophic Factor), Produced from sera of rabbits pre-immunized with highly pure (> |
| Immuno application: |
Western Blot, ELISA |
| Antibody advice: |
This antigen affinity purified antibody, Used in conjunction with compatible secondary reagents the detection limit for recombinant hBDNF is 1, Western Blot: To detect hBDNF by Western Blot analysis this antibody can be used at a concentration of 0, allows the detection of 0, in conjunction with compatible secondary reagents, under either reducing or non-reducing conditions, #956, 0 ng/lane, 1 - 0, 2 - 0, 2 ug/mL, 4 ng/well of recombinant hBDNF, 5 - 3, 5 ug/mL of this antibody is required, ELISA: To detect hBDNF by direct ELISA (using 100 &, L/well antibody solution) a concentration of at least 0 |
| Keep at: |
Avoid repeated freeze-thaw cycles, Frozen aliquots are stable for at least 6 months when stored at -20 grades C, The reconstituted antibody is stable for at least two weeks at 2-8 grades C, BDNF antibody is stable for at least 2 years from date of receipt at -20 grades C |
| Works with: |
Human |
| Omim nr: |
114900 |
| Ncbi nr: |
P23560 |
| Vial with antibody: |
Lyophilized |
| NCBI GENE nr: |
627 |
| GENE symbol: |
BDNF |
| Antigene name: |
brain-derived neurotrophic factor |
| Source: |
Homo sapiens |
| Protein nr: |
P23560 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
BDNF |
| Short name: |
anti-BDNF Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-brain-derived neurotrophic factor (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ANON2 and BULN2, BDNF and IDBG-36817 and ENSG00000176697 and 627, BDNF and IDBG-636102 and ENSBTAG00000008134 and 617701, Bdnf and IDBG-195506 and ENSMUSG00000048482 and 12064, Extracellular, GABAergic and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0033189 and response to vitamin A and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0035864 and response to potassium ion and biological process this GO :0042490 and mechanoreceptor differentiation and biological process this GO :0042493 and response to drug and biological process this GO :0042596 and fear response and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043195 and terminal bouton and cellular component this GO :0043204 and perikaryon and cellular component this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045843 and negative regulation of striated muscle tissue development and biological process this GO :0046668 and regulation of retinal cell programmed cell death and biological process this GO :0048167 and regulation of synaptic plasticity and biological process this GO :0048169 and regulation of long-term neuronal synaptic plasticity and biological process this GO :0048170 and positive regulation of long-term neuronal synaptic plasticity and biological process this GO :0048172 and regulation of short-term neuronal synaptic plasticity and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048675 and axon extension and biological process this GO :0048839 and inner ear development and biological process this GO :0050890 and cognition and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0051965 and positive regulation of synapse assembly and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0060079 and regulation of excitatory postsynaptic membrane potential and biological process this GO :0060548 and negative regulation of cell death and biological process this GO :0061193 and taste bud development and biological process this GO :0071356 and cellular response to tumor necrosis factor and biological process this GO :0071874 and cellular response to norepinephrine stimulus and biological process this GO :0072347 and response to anesthetic and biological process this GO :0097484 and dendrite extension and biological process this GO :1901215 and negative regulation of neuron death and biological process this GO :1902065 and response to L-glutamate and biological process this GO :1990089 and response to nerve growth factor and biological process this GO :1990090 and cellular response to nerve growth factor stimulus and biological process this GO :1990138 and neuron projection extension and biological process, NADH to ubiquinone and biological process this GO :0007214 and gamma-aminobutyric acid signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0007406 and negative regulation of neuroblast proliferation and biological process this GO :0007411 and axon guidance and biological process this GO :0007412 and axon target recognition and biological process this GO :0007611 and learning or memory and biological process this GO :0007612 and learning and biological process this GO :0007623 and circadian rhythm and biological process this GO :0007631 and feeding behavior and biological process this GO :0008021 and synaptic vesicle and cellular component this GO :0008038 and neuron recognition and biological process this GO :0008083 and growth factor activity and molecular function this GO :0009416 and response to light stimulus and biological process this GO :0009642 and response to light intensity and biological process this GO :0009725 and response to hormone and biological process this GO :0010996 and response to auditory stimulus and biological process this GO :0014047 and glutamate secretion and biological process this GO :0014076 and response to fluoxetine and biological process this GO :0014823 and response to activity and biological process this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016358 and dendrite development and biological process this GO :0019222 and regulation of metabolic process and biological process this GO :0021675 and nerve development and biological process this GO :0030061 and mitochondrial crista and cellular component this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0030516 and regulation of axon extension and biological process this GO :0031667 and response to nutrient levels and biological process this GO :0032094 and response to food and biological process this GO :0032229 and negative regulation of synaptic transmission, growth factor activity, this GO :0001657 and ureteric bud development and biological process this GO :0001662 and behavioral fear response and biological process this GO :0001666 and response to hypoxia and biological process this GO :0002544 and chronic inflammatory response and biological process this GO :0005102 and receptor binding and molecular function this GO :0005169 and neurotrophin TRKB receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006120 and mitochondrial electron transport, this GO :0005102 : receptor binding, this GO :0005102 : receptor binding and also this GO :0005169 : neurotrophin TRKB receptor binding and also this GO :0005515 : protein binding and also this GO :0008083 : growth factor activity, this GO :0005169 : neurotrophin TRKB receptor binding, this GO :0005515 : protein binding, this GO :0008083 : growth factor activity, brain-derived neurotrophic factor |
| Identity: |
1033 |
| Gene: |
BDNF |
More about : BDNF |
| Long gene name: |
brain derived neurotrophic factor |
| Synonyms name: |
neurotrophin |
| Locus: |
11p14, 1 |
| Discovery year: |
1991-01-15 |
| GenBank acession: |
AB038670 |
| Entrez gene record: |
627 |
| Pubmed identfication: |
2236018 1889806 17942328 17493809 |
| RefSeq identity: |
NM_170735 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000178797 |