| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
ALEXA FLUOR 594 |
| Host organism: |
Mouse (Mus musculus) |
| Target Protein/Peptide: |
HER2 receptor |
| Specificity: |
Highly specific antibody against HER2 receptor |
| Modification: |
Not modified |
| Clonality: |
Monoclonal Antibodies |
| Clone: |
1A4 |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HER2 receptor |
| Gene ID: |
2064 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross Reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
No significant cross reactivity is observed |
| Background information: |
Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, Alternative splicing results in several additional transcript variants, Amplification and/or overexpression of this gene has been reported in numerous cancers, However, Ile654/Ile655, Jul 2008], This protein has no ligand binding domain of its own and therefore cannot bind growth factors, [provided by RefSeq, including breast and ovarian tumors, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, shown here, some encoding different isoforms and others that have not been fully characterized, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase, with the most common allele, This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases |
| Purification method: |
Purified by Protein G |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, Aqueous buffered solution containing 100ug/ml BSA, C for 12 months |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NEU HER-2 CD340 HER2 |
| Alternative name 1: |
594 Conjugated, ALEXA FLUOR®, HER2 receptor(1A4) Monoclonal Antibody |
| Alternative name 2: |
ALEXA FLUOR 594 Conjugated, HER2 receptor(1A4) Monoclonal anti- |
| Advisory: |
For antibodies in a liquid form or reconstituted lyophilized antibodies - small amounts of the soultion could be captured on the cap or the walls of the container, Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom, specificity and reactivity, Cycles of freezing and thawing should be avoided as such cycles may denature the peptide chains of the antibody and reduce its affinity |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Description: |
2 or 3 and , However, In this sense, When such chemical-signals couple or bind to a receptor, a change in the electrical-activity of a cell, acetylcholine, am olfactory receptor is a protein-molecule that recognizes and responds to , an acetylcholine-receptor recognizes and responds to its endogenous-ligand, chemokinesor cytokines e, e, sometimes in pharmacology, such as enzymes, the term is also used to include other proteins that are drug-targets, they cause some form of cellular/tissue-response, transporters and ion-channels, The receptors are ligand binding factors of type 1, endogenous-chemical signals, g, g, protein-molecules , that receive chemical-signals from outside a cell |
| Gene target: |
HER2 receptor(1A4) Monoclonal |
| Short name: |
Fluor 594, Anti-HER2 receptor(1A4) Monoclonal |
| Technique: |
Monoclonals or monoclonal antibodies |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HER2 receptor(1A4) monoclonal |
| Identity: |
3430 |
| Gene: |
ERBB2 |
More about : ERBB2 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 2 |
| Synonyms gene: |
NGL |
| Synonyms gene name: |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 |
| Synonyms name: |
neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2 |
| Locus: |
17q12 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X03363 |
| Entrez gene record: |
2064 |
| RefSeq identity: |
NM_004448 |
| Classification: |
CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000179300 |
| Locus Specific Databases: |
LRG_724 |