| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CPN2 |
| Specificity: |
This antibody reacts specifically with CPN2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CPN2 |
| Gene ID: |
1370 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Because of the highly conserved active sites and the possible redundant functions of carboxypeptidases, By removing only one amino acid, CPN has the ability to change peptide activity and receptor binding, CPN is a member of a larger family of carboxypeptidases, CPN2, It consists of 2 identical 83 kDa regulatory subunits (CPN2) and 2 identical 50 kDa catalytic subunits (CPN1), It is a 280 kDa tetrameric glycoprotein that is synthesized by the liver and secreted into the plasma, Under some circumstances it may be an allosteric modifier of the catalytic subunit, and cleaves carboxy-terminal arginines and lysines from peptides found in the bloodstream such as complement anaphylatoxins, and creatine kinase MM (CK-MM), binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation, it has been difficult to elucidate the role of CPN in disease processes, kinins, many of which also cleave arginine and lysine, the 83 kDa subunit, CPN2 is a zinc metalloprotease |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CPN2 |
| Also known as: |
CPN2 Polyclonal Antibody |
| Other name: |
Anti-CPN2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CPN2 |
| Short name: |
Anti-CPN2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CPN2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2315 |
| Gene: |
CPNE2 |
More about : CPNE2 |
| Long gene name: |
copine 2 |
| Synonyms gene name: |
copine II |
| Locus: |
16q13 |
| Discovery year: |
1999-02-09 |
| Entrez gene record: |
221184 |
| Pubmed identfication: |
9430674 |
| RefSeq identity: |
NM_152727 |
| Classification: |
Copines |
| Havana BLAST/BLAT: |
OTTHUMG00000133471 |