| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FECH |
| Specificity: |
This antibody reacts specifically with FECH |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human EPB41 |
| Gene ID: |
2235 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in ferrochelatase are associated with protoporphyria, Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway (also called porphyrin pathway), They are broadly classified as hepatic porphyrias or erythropoietic porphyrias, They manifest with either skin problems, Two transcript variants encoding different isoforms have been found for this gene, and is localised in the mitochondrion, based on the site of the overproduction and mainly accumulation of the porphyrins (or their chemical precursors), or neurological complications, or occasionally both, Ferrochelatase catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
FECH Polyclonal Antibody |
| Other name: |
Anti-FECH Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FECH |
| Short name: |
Anti-FECH (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-FECH (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3647 |
| Gene: |
FECH |
More about : FECH |
| Long gene name: |
ferrochelatase |
| Synonyms gene name: |
ferrochelatase (protoporphyria) |
| Synonyms name: |
protoporphyria |
| Locus: |
18q21, 31 |
| Discovery year: |
1990-05-14 |
| GenBank acession: |
D00726 |
| Entrez gene record: |
2235 |
| Pubmed identfication: |
1838349 |
| Havana BLAST/BLAT: |
OTTHUMG00000132740 |
| Locus Specific Databases: |
LRG_1080 |