| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
BMP10 |
| Specificity: |
This antibody reacts specifically with BMP10 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human BMP10 |
| Gene ID: |
27302 |
| Swiss Prot: |
O95393 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, Inhibits endothelial cell migration and growth, May reduce cell migration and cell matrix adhesion in breast cancer cell lines, SMAD5 and SMAD8 transcription factors, leading to activation of SMAD1, Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
BMP10 Polyclonal Antibody |
| Other name: |
Anti-BMP10 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
BMP10 |
| Short name: |
Anti-BMP10 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-bone morphogenetic protein 10 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BMP10 and IDBG-54663 and ENSG00000163217 and 27302, BT, Bmp10 and IDBG-165762 and ENSMUSG00000030046 and 12154, DNA-templated and biological process this GO :0055009 and atrial cardiac muscle tissue morphogenesis and biological process this GO :0055010 and ventricular cardiac muscle tissue morphogenesis and biological process this GO :0055015 and ventricular cardiac muscle cell development and biological process this GO :0055117 and regulation of cardiac muscle contraction and biological process this GO :0060038 and cardiac muscle cell proliferation and biological process this GO :0060045 and positive regulation of cardiac muscle cell proliferation and biological process this GO :0060298 and positive regulation of sarcomere organization and biological process this GO :0060347 and heart trabecula formation and biological process this GO :0060389 and pathway-restricted SMAD protein phosphorylation and biological process this GO :2000138 and positive regulation of cell proliferation involved in heart morphogenesis and biological process, Extracellular, receptor serine/threonine kinase binding, this GO :0005125 and cytokine activity and molecular function this GO :0005179 and hormone activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007507 and heart development and biological process this GO :0007512 and adult heart development and biological process this GO :0008083 and growth factor activity and molecular function this GO :0009986 and cell surface and cellular component this GO :0010596 and negative regulation of endothelial cell migration and biological process this GO :0010613 and positive regulation of cardiac muscle hypertrophy and biological process this GO :0010614 and negative regulation of cardiac muscle hypertrophy and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0010862 and positive regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0014898 and cardiac muscle hypertrophy in response to stress and biological process this GO :0030018 and Z disc and cellular component this GO :0030198 and extracellular matrix organization and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0032924 and activin receptor signaling pathway and biological process this GO :0033612 and receptor serine/threonine kinase binding and molecular function this GO :0040007 and growth and biological process this GO :0045214 and sarcomere organization and biological process this GO :0045893 and positive regulation of transcription, this GO :0005125 : cytokine activity, this GO :0005125 : cytokine activity and also this GO :0005179 : hormone activity and also this GO :0005515 : protein binding and also this GO :0008083 : growth factor activity and also this GO :0033612 : receptor serine/threonine kinase binding, this GO :0005179 : hormone activity, this GO :0005515 : protein binding, this GO :0008083 : growth factor activity, this GO :0033612 : receptor serine/threonine kinase binding, 106443 and IDBG-635729 and ENSBTAG00000000992 and 538874, bone morphogenetic protein 10 |
| Identity: |
20869 |
| Gene: |
BMP10 |
More about : BMP10 |
| Long gene name: |
bone morphogenetic protein 10 |
| Locus: |
2p13, 3 |
| Discovery year: |
2003-04-16 |
| GenBank acession: |
AF101441 |
| Entrez gene record: |
27302 |
| Pubmed identfication: |
10072785 |
| RefSeq identity: |
NM_014482 |
| Classification: |
Endogenous ligands Bone morphogenetic proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000129573 |
| Locus Specific Databases: |
LRG_403 |