| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GHRHR |
| Specificity: |
This antibody reacts specifically with GHRHR |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GHRHR |
| Gene ID: |
2692 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Binding of GHRH leads to the coupling of GHRH-R to G-protein which stimulates increased adenylyl cyclase activity and the accumulation of cAMP leading to the synthesis and release of growth hormone and somatotroph proliferation, GHRH and GHRH-R may also play a role in the regulation of non-rapid eye movement sleep (NREMS), GHRH-R plays an important role in growth and acts as a high-affinity receptor for GHRH, In addition, Mutations in the gene encoding this protein can result in isolated growth hormone deficiency (IGHD), The expression of GHRH-R is dependent on the presence of the POU domain factor Pit-1, also known as Dwarfism of Sindh, and anterior pituitary hypoplasia (APH), reproduction and immune function, this signalling pathway may have direct action in fetal/placental development, GHRH-R is a seven transmembrane domain protein that localizes to the somatotroph of the pituitary |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
GHRHR Polyclonal Antibody |
| Other name: |
Anti-GHRHR Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GHRHR |
| Short name: |
Anti-GHRHR (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GHRHR (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4266 |
| Gene: |
GHRHR |
More about : GHRHR |
| Long gene name: |
growth hormone releasing hormone receptor |
| Locus: |
7p14, 3 |
| Discovery year: |
1993-06-22 |
| Entrez gene record: |
2692 |
| Pubmed identfication: |
7680413 7514564 |
| Classification: |
Glucagon receptor family |
| Havana BLAST/BLAT: |
OTTHUMG00000152801 |