| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MLLT11 |
| Specificity: |
This antibody reacts specifically with MLLT11 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MLLT11 |
| Gene ID: |
10962 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also, Based on the expression patterns of MLLT11, Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and 5% of patients with acute myeloid leukemia (AML), Finally, MLLT11, MLLT11 has been shown to be differentially expressed in highly metastatic cells, MLLT11 is upregulated during neuronal differentiation and is thought to play a role in the development of the central nervous system, Most patients affected are less than 1 year of age, Such findings suggest a role of MLLT11 in tumorigenesis, also known as mixed-lineage leukemia translocated to 11 or AF1q, expressed in embryonic brain cortex, in comparison with non-metastatic parent cells, is a 90 amino acid MLL fusion partner, it is thought that MLLT11 plays a role in leukemogenesis and, specifically, the progression of acute monocytic leukemia (AML), The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
AF1Q |
| Also known as: |
MLLT11 Polyclonal Antibody |
| Other name: |
Anti-MLLT11 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MLLT11 |
| Short name: |
Anti-MLLT11 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
11 (polyclonal), ALEXA Fluor 594, Drosophila), translocated to, antibody to-myeloid/lymphoid and mixed-lineage leukemia (trithorax homolog |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
11, AF1Q, DNA-templated and biological process this GO :0051901 and positive regulation of mitochondrial depolarization and biological process this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process, Drosophila), MLLT11 and IDBG-244926 and ENSG00000213190 and 10962, MLLT11 and IDBG-633245 and ENSBTAG00000015369 and 539519, Mllt11 and IDBG-171976 and ENSMUSG00000053192 and 56772, molecular_function, multiple, this GO :0003674 and molecular function and molecular function this GO :0005622 and intracellular and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045893 and positive regulation of transcription, this GO :0003674 : molecular_function, this GO :0003674 : molecular_function, translocated to, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog |
| Identity: |
16997 |
| Gene: |
MLLT11 |
More about : MLLT11 |
| Long gene name: |
11 , myeloid/lymphoid or mixed-lineage leukemia, translocated to |
| Synonyms gene name: |
11 , Drosophila), myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, translocated to |
| Synonyms name: |
ALL1 fused gene from chromosome 1q |
| Locus: |
1q21, 3 |
| Discovery year: |
2005-05-23 |
| GenBank acession: |
BC006471 |
| Entrez gene record: |
10962 |
| Pubmed identfication: |
7833468 |
| RefSeq identity: |
NM_006818 |
| Havana BLAST/BLAT: |
OTTHUMG00000035160 |