| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ABL1+2Tyr393+439 |
| Specificity: |
This antibody reacts specifically with ABL1+2(Tyr393+439) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr393+439 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human c-Abl around the phosphorylation site of Tyr393 |
| Gene ID: |
25 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Activity of c-Abl protein is negatively regulated by its SH3 domain, The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, The t(9, [provided by RefSeq], and deletion of the SH3 domain turns ABL1 into an oncogene, and stress response, cell adhesion, cell division, suggesting a cell cycle function for ABL1, with alternatively spliced first exons spliced to the common exons 2-11, 22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia, The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
JTK7 c-ABL p150 |
| Also known as: |
ABL1+2(Tyr393+439) Polyclonal Antibody |
| Other name: |
Anti-ABL1+2(Tyr393+439) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ABL1+2(Tyr393+439) |
| Short name: |
Anti-ABL1+2(Tyr393+439) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, non-receptor tyrosine kinase+2(Tyr393+439) (polyclonal), antibody to-c-abl oncogene 1 |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ABL and bcr/abl and c-ABL and c-ABL1 and JTK7 and p150 and v-abl, ABL1 and IDBG-639939 and ENSBTAG00000017976 and 540876, ABL1 and IDBG-89599 and ENSG00000097007 and 25, Abl1 and IDBG-158216 and ENSMUSG00000026842 and 11350, DNA-templated and biological process this GO :0006464 and cellular protein modification process and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006914 and autophagy and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006975 and DNA damage induced protein phosphorylation and biological process this GO :0007155 and cell adhesion and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0010506 and regulation of autophagy and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016772 and transferase activity, non-receptor tyrosine kinase, nuclei, this GO :0000287 and magnesium ion binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003785 and actin monomer binding and molecular function this GO :0004515 and nicotinate-nucleotide adenylyltransferase activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0006298 and mismatch repair and biological process this GO :0006355 and regulation of transcription, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0003677 : DNA binding and also this GO :0003785 : actin monomer binding and also this GO :0004515 : nicotinate-nucleotide adenylyltransferase activity and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0003677 : DNA binding, this GO :0003785 : actin monomer binding, this GO :0004515 : nicotinate-nucleotide adenylyltransferase activity, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0017124 : SH3 domain binding, this GO :0019904 : protein domain specific binding, this GO :0019905 : syntaxin binding, this GO :0030145 : manganese ion binding, this GO :0051019 : mitogen-activated protein kinase binding, this GO :0070064 : proline-rich region binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0017124 : SH3 domain binding and also this GO :0019904 : protein domain specific binding and also this GO :0019905 : syntaxin binding and also this GO :0030145 : manganese ion binding and also this GO :0051019 : mitogen-activated protein kinase binding and also this GO :0070064 : proline-rich region binding, transferring phosphorus-containing groups and molecular function this GO :0017124 and SH3 domain binding and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019904 and protein domain specific binding and molecular function this GO :0019905 and syntaxin binding and molecular function this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030100 and regulation of endocytosis and biological process this GO :0030145 and manganese ion binding and molecular function this GO :0030155 and regulation of cell adhesion and biological process this GO :0031252 and cell leading edge and cellular component this GO :0031965 and nuclear membrane and cellular component this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042692 and muscle cell differentiation and biological process this GO :0042770 and signal transduction in response to DNA damage and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0048008 and platelet-derived growth factor receptor signaling pathway and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0051019 and mitogen-activated protein kinase binding and molecular function this GO :0051149 and positive regulation of muscle cell differentiation and biological process this GO :0051353 and positive regulation of oxidoreductase activity and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0070064 and proline-rich region binding and molecular function this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :2000145 and regulation of cell motility and biological process this GO :2000249 and regulation of actin cytoskeleton reorganization and biological process this GO :2001020 and regulation of response to DNA damage stimulus and biological process, c-abl oncogene 1 |
| Identity: |
76 |
| Gene: |
ABL1 |
More about : ABL1 |
| Long gene name: |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
| Synonyms gene: |
ABL |
| Synonyms gene name: |
non-receptor tyrosine kinase , receptor tyrosine kinase c-abl oncogene 1, v-abl Abelson murine leukemia viral oncogene homolog 1 c-abl oncogene 1 |
| Locus: |
9q34, 12 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M14752 |
| Entrez gene record: |
25 |
| Pubmed identfication: |
1857987 12626632 |
| RefSeq identity: |
NM_007313 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000020813 |
| Locus Specific Databases: |
LRG_769 |