| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RB1CC1 |
| Specificity: |
This antibody reacts specifically with RB1CC1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human RB1CC1 |
| Gene ID: |
9821 |
| Swiss Prot: |
Q8TDY2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis, Expression is, Functions as a DNA-binding transcription factor, Implicated in the regulation of RB1 expression, Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways, Involved in autophagy, Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation, Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity), Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1, Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S, a prerequisite for myogenic differentiation, thus, Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111, typhimurium infection and subsequent xenophagy |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA0203 Cc1 DRAGOU14 FIP200 ATG17 PPP1R131 |
| Also known as: |
RB1CC1 Polyclonal Antibody |
| Other name: |
Anti-RB1CC1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RB1CC1 |
| Short name: |
Anti-RB1CC1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-retinoblastoma 1-inducible coiled-coil 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ATG17 and CC1 and FIP200 and PPP1R131, BT, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0007049 and cell cycle and biological process this GO :0007254 and JNK cascade and biological process this GO :0007507 and heart development and biological process this GO :0010506 and regulation of autophagy and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0031965 and nuclear membrane and cellular component this GO :0034045 and pre-autopha this GO somal structure membrane and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045793 and positive regulation of cell size and biological process this GO :0070969 and ULK1-ATG13-FIP200 complex and cellular component this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process, RB1CC1 and IDBG-21487 and ENSG00000023287 and 9821, Rb1cc1 and IDBG-131892 and ENSMUSG00000025907 and 12421, nuclei, protein kinase binding, this GO :0000045 and autophagic vacuole assembly and biological process this GO :0000407 and pre-autopha this GO somal structure and cellular component this GO :0001889 and liver development and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0019901 : protein kinase binding, this GO :0019901 : protein kinase binding, 55953 and IDBG-644388 and ENSBTAG00000000878 and 539858, RB1-inducible coiled-coil 1 |
| Identity: |
15574 |
| Gene: |
RB1CC1 |
More about : RB1CC1 |
| Long gene name: |
RB1 inducible coiled-coil 1 |
| Synonyms name: |
200 kDa FAK family kinase-interacting protein phosphatase 1, regulatory subunit 131 |
| Locus: |
8q11, 23 |
| Discovery year: |
2001-06-01 |
| GenBank acession: |
AB059622 |
| Entrez gene record: |
9821 |
| Pubmed identfication: |
11850849 7724523 18443221 |
| RefSeq identity: |
NM_014781 |
| Classification: |
Autophagy related Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000164268 |