| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Lipin 1 |
| Specificity: |
This antibody reacts specifically with Lipin 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Lipin 1 |
| Gene ID: |
23175 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Rat (Rattus norvegicus), Mouse (Mus musculus) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism, LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels, LPIN1 selectively activates a subset of PGC1 alpha target pathways, Lipin 2 and Lipin 3, This family contains three members: Lipin 1, a heterogeneous group of disorders characterized by loss of body fat, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain, all of which contain a nuclear signal sequence, fatty liver, hypertriglyceridemia and insulin resistance, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha, resulting in insulin resistance and lipodystrophy, whereas a deficiency in LPIN1 may deter normal adipose tissue development, Lipin 1 is a member of the Lipin family of nuclear proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA0188 |
| Also known as: |
Lipin 1 Polyclonal Antibody |
| Other name: |
Anti-Lipin 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Lipin 1 |
| Short name: |
Anti-Lipin 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Lipin 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
13345 |
| Gene: |
LPIN1 |
More about : LPIN1 |
| Long gene name: |
lipin 1 |
| Locus: |
2p25, 1 |
| Discovery year: |
2001-01-24 |
| GenBank acession: |
D80010 |
| Entrez gene record: |
23175 |
| Pubmed identfication: |
11138012 8724849 16950137 |
| RefSeq identity: |
NM_145693 |
| Classification: |
Lipins |
| Havana BLAST/BLAT: |
OTTHUMG00000119082 |