| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
DOCK1 |
| Specificity: |
This antibody reacts specifically with DOCK1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human DOCK1 |
| Gene ID: |
1793 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Expressed at intermediate level in thymus, Functions as a guanine nucleotide exchange factor (GEF), Its GEF activity may be enhanced by ELMO1, kidney, lung, pancreas and ovary, testes and colon, which activates Rac Rho small GTPases by exchanging bound GDP for free GTP, Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility, Tissue specificity: Highly expressed in placenta |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DOCK180 ced5 |
| Also known as: |
DOCK1 Polyclonal Antibody |
| Other name: |
Anti-DOCK1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
DOCK1 |
| Short name: |
Anti-DOCK1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-dedicator on cytokinesis 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DOCK1 and IDBG-640952 and ENSBTAG00000031890 and 537203, DOCK1 and IDBG-93118 and ENSG00000150760 and 1793, Dock1 and IDBG-211315 and ENSMUSG00000058325 and 330662, ced5 and DOCK180, engulfment and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0009055 and electron carrier activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016477 and cell migration and biological process this GO :0017124 and SH3 domain binding and molecular function this GO :0020037 and heme binding and molecular function this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0045087 and innate immune response and biological process, heme binding, nuclei, this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005096 and GTPase activator activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006911 and pha this GO cytosis, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005096 : GTPase activator activity and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0009055 : electron carrier activity and also this GO :0017124 : SH3 domain binding and also this GO :0020037 : heme binding, this GO :0005096 : GTPase activator activity, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0009055 : electron carrier activity, this GO :0017124 : SH3 domain binding, this GO :0020037 : heme binding, dedicator of cytokinesis 1 |
| Identity: |
2987 |
| Gene: |
DOCK1 |
More about : DOCK1 |
| Long gene name: |
dedicator of cytokinesis 1 |
| Synonyms gene name: |
dedicator of cyto-kinesis 1 |
| Synonyms name: |
DOwnstream of CrK |
| Locus: |
10q26, 2 |
| Discovery year: |
1998-05-13 |
| GenBank acession: |
D50857 |
| Entrez gene record: |
1793 |
| Pubmed identfication: |
8657152 8661160 |
| RefSeq identity: |
NM_001380 |
| Havana BLAST/BLAT: |
OTTHUMG00000019249 |