| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SCN8A |
| Specificity: |
This antibody reacts specifically with SCN8A |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
6, KLH conjugated synthetic peptide derived from human SCN8A/Nav1 |
| Gene ID: |
6334 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Assuming opened or closed conformations in response to the voltage difference across the membrane, In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient, Mediates the voltage-dependent sodium ion permeability of excitable membranes |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Nav1, 6 NaCh6 PN4 CerIII |
| Also known as: |
SCN8A Polyclonal Antibody |
| Other name: |
Anti-SCN8A Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SCN8A |
| Short name: |
Anti-SCN8A (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SCN8A (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
10596 |
| Gene: |
SCN8A |
More about : SCN8A |
| Long gene name: |
sodium voltage-gated channel alpha subunit 8 |
| Synonyms gene: |
MED |
| Synonyms gene name: |
alpha polypeptide sodium channel, alpha subunit sodium channel, sodium channel, type VIII, type VIII, type VIII alpha subunit , voltage gated, voltage gated, voltage gated |
| Locus: |
12q13, 1 |
| Discovery year: |
1995-08-23 |
| GenBank acession: |
AB027567 |
| Entrez gene record: |
6334 |
| Pubmed identfication: |
7670495 9828131 16382098 |
| RefSeq identity: |
NM_014191 |
| Classification: |
Sodium voltage-gated channel alpha subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000169490 |