| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Bcr Tyr360 |
| Specificity: |
This antibody reacts specifically with Bcr (Tyr360) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr360 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human Bcr around the phosphorylation site of Tyr360 [TT(p-Y)RM] |
| Gene ID: |
613 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Although the BCR-ABL fusion protein has been extensively studied, The chromosome 22 breakpoint for this translocation is located within the BCR gene, The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac, The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, Two transcript variants encoding different isoforms have been found for this gene, the function of the normal BCR gene product is not clear, the gene at the chromosome 9 breakpoint, which is often found in patients with chronic myelogenous leukemia, A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ALL, BCR 1, BCR/ABL FUSION GENE INCLUDED, BCR/FGFR1 FUSION GENE INCLUDED, BCR/PDGFRA FUSION GENE INCLUDED, BCR1, BCR_HUMAN, Bcrphospho Y360, CML, P-Bcrphospho Y360, PHL, breakpoint cluster region, Bcr phospho Y360 |
| Also known as: |
Bcr (Tyr360) Polyclonal Antibody |
| Other name: |
Anti-Bcr (Tyr360) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Bcr (Tyr360) |
| Short name: |
Anti-Bcr (Tyr360) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Bcr (Tyr360) (polyclonal) |
| Alternative technique: |
polyclonals |