| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MAPK8IP1 |
| Specificity: |
This antibody reacts specifically with MAPK8IP1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human JIP1/MAPK8IP1 |
| Gene ID: |
9479 |
| Swiss Prot: |
Q9UQF2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Appears to have a role in cell signaling in mature and developing nerve terminals, Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun, Directly, Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response, May also participate in ApoER2-specific reelin signaling, May function as a regulator of vesicle transport, Required for JNK activation in response to excitotoxic stress, or indirectly, regulates GLUT2 gene expression and beta-cell function, through interactions with the JNK-signaling components and motor proteins (By similarity), The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
IB1 JIP-1 JIP1 |
| Also known as: |
MAPK8IP1 Polyclonal Antibody |
| Other name: |
Anti-MAPK8IP1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MAPK8IP1 |
| Short name: |
Anti-MAPK8IP1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-mitogen-activated protein phosphorylation catalyst 8 interacting protein 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BT, DNA-templated and biological process this GO :0007165 and signal transduction and biological process this GO :0007258 and JUN phosphorylation and biological process this GO :0008432 and JUN kinase binding and molecular function this GO :0009967 and positive regulation of signal transduction and biological process this GO :0016020 and membrane and cellular component this GO :0016192 and vesicle-mediated transport and biological process this GO :0019894 and kinesin binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031434 and mitogen-activated protein kinase kinase binding and molecular function this GO :0031435 and mitogen-activated protein kinase kinase kinase binding and molecular function this GO :0031966 and mitochondrial membrane and cellular component this GO :0042802 and identical protein binding and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043508 and negative regulation of JUN kinase activity and biological process this GO :0044294 and dendritic growth cone and cellular component this GO :0044295 and axonal growth cone and cellular component this GO :0044297 and cell body and cellular component this GO :0044302 and dentate gyrus mossy fiber and cellular component this GO :0045202 and synapse and cellular component this GO :0046328 and regulation of JNK cascade and biological process this GO :0046329 and negative regulation of JNK cascade and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, IB1 and JIP-1 and JIP1 and PRKM8IP, MAPK8IP1 and IDBG-41200 and ENSG00000121653 and 9479, Mapk8ip1 and IDBG-192264 and ENSMUSG00000027223 and 19099, identical protein binding, nuclei, this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005078 and MAP-kinase scaffold activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0004860 : protein kinase inhibitor activity, this GO :0004860 : protein kinase inhibitor activity and also this GO :0005078 : MAP-kinase scaffold activity and also this GO :0005515 : protein binding and also this GO :0008432 : JUN kinase binding and also this GO :0019894 : kinesin binding and also this GO :0019901 : protein kinase binding and also this GO :0031434 : mitogen-activated protein kinase kinase binding and also this GO :0031435 : mitogen-activated protein kinase kinase kinase binding and also this GO :0042802 : identical protein binding, this GO :0005078 : MAP-kinase scaffold activity, this GO :0005515 : protein binding, this GO :0008432 : JUN kinase binding, this GO :0019894 : kinesin binding, this GO :0019901 : protein kinase binding, this GO :0031434 : mitogen-activated protein kinase kinase binding, this GO :0031435 : mitogen-activated protein kinase kinase kinase binding, this GO :0042802 : identical protein binding, 105291 and IDBG-637017 and ENSBTAG00000000317 and 524806, mitogen-activated protein kinase 8 interacting protein 1 |
| Identity: |
6882 |
| Gene: |
MAPK8IP1 |
More about : MAPK8IP1 |
| Long gene name: |
mitogen-activated protein kinase 8 interacting protein 1 |
| Synonyms gene: |
PRKM8IP |
| Locus: |
11p11, 2 |
| Discovery year: |
1999-06-11 |
| Entrez gene record: |
9479 |
| Pubmed identfication: |
9235893 9442013 |
| RefSeq identity: |
NM_005456 |
| Havana BLAST/BLAT: |
OTTHUMG00000134324 |