| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ACVR1B |
| Specificity: |
This antibody reacts specifically with ACVR1B |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ACVR1B |
| Gene ID: |
91 |
| Swiss Prot: |
P36896 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ACVR1B also phosphorylates TDP2, Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase, Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary, Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor, FSH production by the pituitary gland, Inhibitory SMAD7, Once activated, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4, Soon after their association with the activin receptor and subsequent phosphorylation, The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B, This SMAD complex translocates into the nucleus where it mediates activin-induced transcription, Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, Within the receptor complex, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, extracellular matrix production, hair follicle development and cycling, immunosuppression and carcinogenesis, on serine residues of the C-terminal tail, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, thereby blocking the activin signal, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals, which is recruited to ACVR1B through FKBP1A, wound healing, Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ALK4 SKR2 ActRIB |
| Also known as: |
ACVR1B Polyclonal Antibody |
| Other name: |
Anti-ACVR1B Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ACVR1B |
| Short name: |
Anti-ACVR1B (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, classification IB (polyclonal), antibody to-activin A receptor |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ACTRIB and ACVRLK4 and ALK4 and SKR2, ACVR1B and IDBG-33695 and ENSG00000135503 and 91, ACVR1B and IDBG-632110 and ENSBTAG00000013555 and 539315, Acvr1b and IDBG-185560 and ENSMUSG00000000532 and 11479, Cell surfaces, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007178 and transmembrane receptor protein serine/threonine kinase signaling pathway and biological process this GO :0007417 and central nervous system development and biological process this GO :0009966 and regulation of signal transduction and biological process this GO :0009986 and cell surface and cellular component this GO :0010862 and positive regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0016020 and membrane and cellular component this GO :0016361 and activin receptor activity, activin receptor activity, this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001942 and hair follicle development and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006355 and regulation of transcription, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702 : receptor signaling protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016361 : activin receptor activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity, this GO :0004702 : receptor signaling protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016361 : activin receptor activity, this GO :0016772 : transferase activity, this GO :0017002 : activin-activated receptor activity, this GO :0019838 : growth factor binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0034711 : inhibin binding, this GO :0046332 : SMAD binding, this GO :0046872 : metal ion binding, this GO :0048185 : activin binding, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0017002 : activin-activated receptor activity and also this GO :0019838 : growth factor binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0034711 : inhibin binding and also this GO :0046332 : SMAD binding and also this GO :0046872 : metal ion binding and also this GO :0048185 : activin binding, transferring phosphorus-containing groups and molecular function this GO :0017002 and activin-activated receptor activity and molecular function this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0019838 and growth factor binding and molecular function this GO :0030308 and negative regulation of cell growth and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032924 and activin receptor signaling pathway and biological process this GO :0032927 and positive regulation of activin receptor signaling pathway and biological process this GO :0034711 and inhibin binding and molecular function this GO :0038092 and nodal signaling pathway and biological process this GO :0045648 and positive regulation of erythrocyte differentiation and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046545 and development of primary female sexual characteristics and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048185 and activin binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :1901165 and positive regulation of trophoblast cell migration and biological process, type I, type I and also this GO :0016772 : transferase activity, type I and molecular function this GO :0016772 and transferase activity, type IB, activin A receptor |
| Identity: |
172 |
| Gene: |
ACVR1B |
More about : ACVR1B |
| Long gene name: |
activin A receptor type 1B |
| Synonyms gene: |
ACVRLK4 |
| Synonyms gene name: |
activin A receptor, type IB |
| Locus: |
12q13, 13 |
| Discovery year: |
1994-12-12 |
| Entrez gene record: |
91 |
| Pubmed identfication: |
8397373 |
| RefSeq identity: |
NM_020328 |
| Classification: |
Type 1 receptor serine/threonine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000167920 |