| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ANGPTL3 |
| Specificity: |
This antibody reacts specifically with ANGPTL3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ANG5/ANGPTL3 |
| Gene ID: |
27329 |
| Swiss Prot: |
Q9Y5C1 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A deficiency of Angptl3 results in abnormally low lipid levels, Angptl3 also plays a role in adipose formation and angiogenesis through its interaction with integrin ?v)beta(3), Angptl3 may also play an important role in hyperlipidemia in diabetes, Angptl3 regulates circulating triglyceride levels during different nutritional states thereby mediating the feeding/fasting cycle, It is secreted by the liver and is functionally defined by the C-terminal fibrinogen (FBN)-like domain and an N-terminal coiled-coil domain, and a repression of the protein may be protective against atherosclerosis, Angiopoietin-like protein 3 (Angptl3) functions as a potent lipoprotein lipase inhibitor and is an important component of plasma triglyceride homeostasis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
ANGPTL3 Polyclonal Antibody |
| Other name: |
Anti-ANGPTL3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ANGPTL3 |
| Short name: |
Anti-ANGPTL3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-angiopoietin-like 3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ANGPTL3 and IDBG-638594 and ENSBTAG00000021386 and 782603, ANGPTL3 and IDBG-99367 and ENSG00000132855 and 27329, Angptl3 and IDBG-166252 and ENSMUSG00000028553 and 30924, Extracellular, growth factor activity, this GO :0004857 and enzyme inhibitor activity and molecular function this GO :0004859 and phospholipase inhibitor activity and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0006071 and glycerol metabolic process and biological process this GO :0006631 and fatty acid metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0008083 and growth factor activity and molecular function this GO :0008203 and cholesterol metabolic process and biological process this GO :0009395 and phospholipid catabolic process and biological process this GO :0009725 and response to hormone and biological process this GO :0009986 and cell surface and cellular component this GO :0010519 and negative regulation of phospholipase activity and biological process this GO :0019915 and lipid storage and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0048844 and artery morphogenesis and biological process this GO :0050996 and positive regulation of lipid catabolic process and biological process this GO :0051005 and negative regulation of lipoprotein lipase activity and biological process this GO :0055088 and lipid homeostasis and biological process this GO :0055090 and acylglycerol homeostasis and biological process this GO :0055091 and phospholipid homeostasis and biological process this GO :0070328 and triglyceride homeostasis and biological process, this GO :0004857 : enzyme inhibitor activity, this GO :0004857 : enzyme inhibitor activity and also this GO :0004859 : phospholipase inhibitor activity and also this GO :0005178 : integrin binding and also this GO :0008083 : growth factor activity, this GO :0004859 : phospholipase inhibitor activity, this GO :0005178 : integrin binding, this GO :0008083 : growth factor activity, angiopoietin-like 3 |
| Identity: |
491 |
| Gene: |
ANGPTL3 |
More about : ANGPTL3 |
| Long gene name: |
angiopoietin like 3 |
| Synonyms gene: |
ANGPT5 |
| Synonyms gene name: |
angiopoietin-like 3 |
| Synonyms name: |
angiopoietin 5 |
| Locus: |
1p31, 3 |
| Discovery year: |
2000-02-07 |
| GenBank acession: |
AF152562 |
| Entrez gene record: |
27329 |
| Pubmed identfication: |
10644446 |
| RefSeq identity: |
NM_014495 |
| Classification: |
Fibrinogen C domain containing Angiopoietin like |
| Havana BLAST/BLAT: |
OTTHUMG00000009146 |