| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
NFKB1 Ser907 |
| Specificity: |
This antibody reacts specifically with NFKB1 (Ser907) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser907 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human NF KappaB p105 around the phosphorylation site of Ser907 |
| Gene ID: |
4790 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions, Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth, NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, Sep 2009], The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex, Two transcript variants encoding different isoforms have been found for this gene, [provided by RefSeq, and bacterial or viral products, oxidant-free radicals, ultraviolet irradiation, This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KBF1 p105 NFKB-p50 p50 NF-kappaB NFkappaB NF-kB1 |
| Also known as: |
NFKB1 (Ser907) Polyclonal Antibody |
| Other name: |
Anti-NFKB1 (Ser907) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
NFKB1 (Ser907) |
| Short name: |
Anti-NFKB1 (Ser907) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-nuclear factor on kappa light polypeptide gene enhancer in B-cells 1 (Ser907) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BT, DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007165 and signal transduction and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0009617 and response to bacterium and biological process this GO :0010744 and positive regulation of macrophage derived foam cell differentiation and biological process this GO :0010884 and positive regulation of lipid storage and biological process this GO :0010956 and negative regulation of calcidiol 1-monooxygenase activity and biological process this GO :0010957 and negative regulation of vitamin D biosynthetic process and biological process this GO :0031072 and heat shock protein binding and molecular function this GO :0031293 and membrane protein intracellular domain proteolysis and biological process this GO :0032269 and negative regulation of cellular protein metabolic process and biological process this GO :0032375 and negative regulation of cholesterol transport and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0033256 and I-kappaB/NF-kappaB complex and cellular component this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045083 and negative regulation of interleukin-12 biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046688 and response to copper ion and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071316 and cellular response to nicotine and biological process this GO :0071347 and cellular response to interleukin-1 and biological process this GO :0071354 and cellular response to interleukin-6 and biological process this GO :0071375 and cellular response to peptide hormone stimulus and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process this GO :1900127 and positive regulation of hyaluronan biosynthetic process and biological process this GO :2000630 and positive regulation of miRNA metabolic process and biological process, EBP-1 and KBF1 and NF-kappa-B and NF-kappaB and NF-kB1 and NFkappaB and NFKB-p105 and NFKB-p50 and p105 and p50, NFKB1 and IDBG-31974 and ENSG00000109320 and 4790, Nfkb1 and IDBG-195445 and ENSMUSG00000028163 and 18033, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000975 and regulatory region DNA binding and molecular function this GO :0000976 and transcription regulatory region sequence-specific DNA binding and molecular function this GO :0001071 and nucleic acid binding transcription factor activity and molecular function this GO :0001818 and negative regulation of cytokine production and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003677 and DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0000975 : regulatory region DNA binding, this GO :0000975 : regulatory region DNA binding and also this GO :0000976 : transcription regulatory region sequence-specific DNA binding and also this GO :0001071 : nucleic acid binding transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003690 : double-stranded DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0031072 : heat shock protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043565 : sequence-specific DNA binding and also this GO :0044212 : transcription regulatory region DNA binding, this GO :0000976 : transcription regulatory region sequence-specific DNA binding, this GO :0001071 : nucleic acid binding transcription factor activity, this GO :0003677 : DNA binding, this GO :0003690 : double-stranded DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0031072 : heat shock protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043565 : sequence-specific DNA binding, this GO :0044212 : transcription regulatory region DNA binding, transcription regulatory region DNA binding, 60919 and IDBG-640840 and ENSBTAG00000020270 and 616115, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Identity: |
7794 |
| Gene: |
NFKB1 |
More about : NFKB1 |
| Long gene name: |
nuclear factor kappa B subunit 1 |
| Synonyms gene name: |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Locus: |
4q24 |
| Discovery year: |
1991-11-14 |
| GenBank acession: |
M58603 |
| Entrez gene record: |
4790 |
| Pubmed identfication: |
1992489 |
| RefSeq identity: |
NM_003998 |
| Classification: |
Ankyrin repeat domain containing NF-kappa B complex subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000161080 |