| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HER4 Tyr1162 |
| Specificity: |
This antibody reacts specifically with HER4 (Tyr1162) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr1162 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human HER4 around the phosphorylation site of Tyr1162 |
| Gene ID: |
2066 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Alternatively spliced variants which encode different protein isoforms have been described, It encodes a single-pass type I membrane protein with multiple cysteine rich domains, Jul 2008], Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment, Mutations in this gene have been associated with cancer, The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation, [provided by RefSeq, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif, a transmembrane domain, a tyrosine kinase domain, however, not all variants have been fully characterized, This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ALS19 HER4 |
| Also known as: |
HER4 (Tyr1162) Polyclonal Antibody |
| Other name: |
Anti-HER4 (Tyr1162) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HER4 (Tyr1162) |
| Short name: |
Anti-HER4 (Tyr1162) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HER4 (Tyr1162) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3432 |
| Gene: |
ERBB4 |
More about : ERBB4 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms gene name: |
v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
| Synonyms name: |
human epidermal growth factor receptor 4 |
| Locus: |
2q34 |
| Discovery year: |
1995-09-07 |
| GenBank acession: |
L07868 |
| Entrez gene record: |
2066 |
| Pubmed identfication: |
7700649 17018285 |
| RefSeq identity: |
NM_001042599 |
| Classification: |
Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000133012 |