| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Desmin Thr76 + Thr77 |
| Specificity: |
This antibody reacts specifically with Desmin (Thr76 + Thr77) |
| Modification: |
Phosphorylation |
| Modification site: |
Thr76 + Thr77 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human DES around the phosphorylation site of Thr76/Thr77 |
| Gene ID: |
1674 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A desmin related myopathy can have a distal onset, Antidesmin are useful in identification of tumours of myogenic origin, CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function, CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I), Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM), In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells, arrhythmias, it is then known as hereditary distal myopathy (HDM), restrictive heart failure, filaments found in muscle cells |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CMD1I, CSM1, CSM2, DES, DESM_HUMAN, Desmin, Desmin phospho Thr76+Thr77, Desmin phospho Thr76/Thr77, FLJ12025, FLJ12025, FLJ39719, FLJ39719, FLJ41013, FLJ41013, FLJ41793, FLJ41793, Intermediate filament protein, OTTHUMP00000064865, p-Desmin Thr76/Thr77, Desmin phospho T76/77 |
| Also known as: |
Desmin (Thr76 + Thr77) Antibody |
| Other name: |
Anti-Desmin (Thr76 + Thr77) |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene: |
DSM1 and DSM2 play an important role in Desminopathy, Desmin regulated Myofibrilate Myopathy is a protein filament mutation of muscle proteins, Desmins or DES proteins detect by anti-desmin antibodies and DES ELISA kits |
More about : DSM1 and DSM2 play an important role in Desminopathy, Desmin regulated Myofibrilate Myopathy is a protein filament mutation of muscle proteins, Desmins or DES proteins detect by anti-desmin antibodies and DES ELISA kits |
| Gene target: |
Desmin (Thr76 + Thr77) |
| Short name: |
Anti-Desmin (Thr76 + Thr77) Fluor 594 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Desmin (Thr76 and Thr77) |