| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
DOK1 Tyr398 |
| Specificity: |
This antibody reacts specifically with DOK1 (Tyr398) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr398 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr398 |
| Gene ID: |
1796 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs, Docking protein 2 binds p120 (RasGAP) from CML cells, It has been postulated to play a role in mitogenic signaling, It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML, Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
p62dok |
| Also known as: |
DOK1 (Tyr398) Polyclonal Antibody |
| Other name: |
Anti-DOK1 (Tyr398) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
DOK1 (Tyr398) |
| Short name: |
Anti-DOK1 (Tyr398) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
62kDa (downstream on tyrosine kinase 1) (Tyr398) (polyclonal), ALEXA Fluor 594, antibody to-docking protein 1 |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
62kDa (downstream of tyrosine kinase 1), DOK1 and IDBG-57879 and ENSG00000115325 and 1796, DOK1 and IDBG-631228 and ENSBTAG00000018579 and 514962, Dok1 and IDBG-159342 and ENSMUSG00000068335 and 13448, P62DOK, nuclei, protein binding, this GO :0005057 and receptor signaling protein activity and molecular function this GO :0005158 and insulin receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component, this GO :0005057 : receptor signaling protein activity, this GO :0005057 : receptor signaling protein activity and also this GO :0005158 : insulin receptor binding and also this GO :0005515 : protein binding, this GO :0005158 : insulin receptor binding, this GO :0005515 : protein binding, docking protein 1 |
| Identity: |
2990 |
| Gene: |
DOK1 |
More about : DOK1 |
| Long gene name: |
docking protein 1 |
| Synonyms gene name: |
62kD (downstream of tyrosine kinase 1) docking protein 1, 62kDa (downstream of tyrosine kinase 1) , docking protein 1 |
| Synonyms name: |
downstream of tyrosine kinase 1 |
| Locus: |
2p13, 1 |
| Discovery year: |
1997-07-25 |
| GenBank acession: |
U70987 |
| Entrez gene record: |
1796 |
| Pubmed identfication: |
9008160 9790776 15546884 |
| RefSeq identity: |
NM_001381 |
| Havana BLAST/BLAT: |
OTTHUMG00000129956 |