| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ETS1 associated protein II |
| Specificity: |
This antibody reacts specifically with ETS1 associated protein II |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ETS1 associated protein II/EAPII |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue, Has also 3'-tyrosyl DNA phosphodiesterase activity, Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals, May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation, The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, but less efficiently and much slower than TDP1, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation, giving rise to DNA with a free 5' phosphate, DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FLJ10768 ETS-1 |
| Also known as: |
ETS1 associated protein II Antibody |
| Other name: |
Anti-ETS1 associated protein II |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
ETS1 associated protein II |
| Short name: |
Fluor 594, Anti-ETS1 associated protein II |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) associated protein II |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006955 and immune response and biological process this GO :0007565 and female pregnancy and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009611 and response to wounding and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0010595 and positive regulation of endothelial cell migration and biological process this GO :0010715 and regulation of extracellular matrix disassembly and biological process this GO :0021854 and hypothalamus development and biological process this GO :0021983 and pituitary gland development and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030578 and PML body organization and biological process this GO :0032355 and response to estradiol and biological process this GO :0034616 and response to laminar fluid shear stress and biological process this GO :0035035 and histone acetyltransferase binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045171 and intercellular bridge and cellular component this GO :0045648 and positive regulation of erythrocyte differentiation and biological process this GO :0045765 and regulation of angiogenesis and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045786 and negative regulation of cell cycle and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046677 and response to antibiotic and biological process this GO :0048870 and cell motility and biological process this GO :0051272 and positive regulation of cellular component movement and biological process this GO :0060055 and angiogenesis involved in wound healing and biological process this GO :0060206 and estrous cycle phase and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0070555 and response to interleukin-1 and biological process, ETS-1 and EWSR2 and p54, ETS1 and IDBG-642787 and ENSBTAG00000002341 and 540313, ETS1 and IDBG-75897 and ENSG00000134954 and 2113, Ets1 and IDBG-147548 and ENSMUSG00000032035 and 23871, nuclei, sequence-specific DNA binding, this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0001666 and response to hypoxia and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006355 and regulation of transcription, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0035035 : histone acetyltransferase binding and also this GO :0043565 : sequence-specific DNA binding, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0035035 : histone acetyltransferase binding, this GO :0043565 : sequence-specific DNA binding, v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) |
| Identity: |
3488 |
| Gene: |
ETS1 |
More about : ETS1 |
| Long gene name: |
ETS proto-oncogene 1, transcription factor |
| Synonyms gene: |
EWSR2 |
| Synonyms gene name: |
v-ets avian erythroblastosis virus E26 oncogene homolog 1 |
| Synonyms name: |
Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1 ets protein |
| Locus: |
11q24, 3 |
| Discovery year: |
1986-01-01 |
| Entrez gene record: |
2113 |
| Pubmed identfication: |
1522903 |
| RefSeq identity: |
NM_005238 |
| Classification: |
ETS transcription factor family |
| Havana BLAST/BLAT: |
OTTHUMG00000165799 |