| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Lamin B Receptor |
| Specificity: |
This antibody reacts specifically with Lamin B Receptor |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Lamin B Receptor |
| Gene ID: |
3930 |
| Swiss Prot: |
Q14739 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin, It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures, Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane, The cleavage of lamins results in nuclear disregulation and cell death, such as DNA replication and chromatin organization, Lamins are nuclear membrane proteins that serve to maintain specific cellular functions |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DHCR14B TDRD18 |
| Also known as: |
Lamin B Receptor Polyclonal Antibody |
| Other name: |
Anti-Lamin B Receptor Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Lamin B Receptor |
| Short name: |
Anti-Lamin B Receptor (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Lamin B Receptor (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
6518 |
| Gene: |
LBR |
More about : LBR |
| Long gene name: |
lamin B receptor |
| Synonyms name: |
tudor domain containing 18 |
| Locus: |
1q42, 12 |
| Discovery year: |
1995-04-27 |
| GenBank acession: |
L25931 |
| Entrez gene record: |
3930 |
| Pubmed identfication: |
8157663 9878250 |
| RefSeq identity: |
NM_002296 |
| Classification: |
Tudor domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000037520 |