| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MICA/MHCI a |
| Specificity: |
This antibody reacts specifically with MICA/MHCI a |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from mouse MICA/MHCI a |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Rat (Rattus norvegicus), Mouse (Mus musculus) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
MICA, MICA is present in virtually every tissue except the nervous system, The MHC class I chain-related (MIC) proteins are recognized by NKG2D, a member of the MIC family, a receptor on NK and T cells, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes, and promote anti-tumor activity, is widely expressed on many tumors, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system, The MHC class I chain-related (MIC) proteins are related to the Major histocompatibility complex (MHC) class I proteins which are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PERB11, 1 |
| Also known as: |
MICA/MHCI a Polyclonal Antibody |
| Other name: |
Anti-MICA/MHCI a Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MICA/MHCI a |
| Short name: |
Anti-MICA/MHCI a (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Major histocompabitility complex class I polypeptide-related sequence A/MHCI a (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
MICA and IDBG-77578 and ENSG00000204520 and 100507436, Plasma membranes, protein binding, this GO :0005515 and protein binding and molecular function this GO :0006955 and immune response and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019882 and antigen processing and presentation and biological process this GO :0045087 and innate immune response and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, MHC class I polypeptide-related sequence A |
| Identity: |
7090 |
| Gene: |
MICA |
More about : MICA |
| Long gene name: |
MHC class I polypeptide-related sequence A |
| Locus: |
6p21, 33 |
| Discovery year: |
1994-05-16 |
| GenBank acession: |
L14848 |
| Entrez gene record: |
100507436 |
| Pubmed identfication: |
8022771 |
| RefSeq identity: |
NM_001177519 |
| Classification: |
C1-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031073 |
| Locus Specific Databases: |
IMGT/HLA Database |