| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
LMP2 |
| Specificity: |
This antibody reacts specifically with LMP2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Helical, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from HHV4t2 LMP2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Virus |
| Cross Reactive Species details: |
HHV4t2 |
| Background information: |
EBV latently infects B lymphocytes, Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B, LMP2A forms aggregates in the plasma membranes of B lymphocytes, Most people become infected with EBV during their lives, Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals, nasopharyngeal carcinoma and Hodgkin's disease, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases, Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
RING12 beta1i PSMB6i |
| Also known as: |
LMP2 Polyclonal Antibody |
| Other name: |
Anti-LMP2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
LMP2 |
| Short name: |
Anti-LMP2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-LMP2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9546 |
| Gene: |
PSMB9 |
More about : PSMB9 |
| Long gene name: |
proteasome subunit beta 9 |
| Synonyms gene: |
LMP2 |
| Synonyms gene name: |
9 , 9 (large multifunctional protease 2) large multifunctional peptidase 2 proteasome (prosome, beta type, beta type, macropain) subunit, macropain) subunit, proteasome (prosome |
| Locus: |
6p21, 32 |
| Discovery year: |
1991-12-18 |
| Entrez gene record: |
5698 |
| Pubmed identfication: |
1922385 1529427 |
| RefSeq identity: |
NM_002800 |
| Classification: |
Proteasome |
| Havana BLAST/BLAT: |
OTTHUMG00000031287 |