| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PP2CA |
| Specificity: |
This antibody reacts specifically with PP2CA |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PP2CA |
| Gene ID: |
5494 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses, Jul 2008], MAP kinases and MAP kinase kinases, Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, PP2C family members are known to be negative regulators of cell stress response pathways, This phosphatase can also dephosphorylate cyclin-dependent kinases, This phosphatase dephosphorylates, Three alternatively spliced transcript variants encoding distinct isoforms have been described, [provided by RefSeq, and negatively regulates the activities of, and thus may be involved in cell cycle control, which leads to G2/M cell cycle arrest and apoptosis, The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MGC9201 PP2Calpha PP2CA |
| Also known as: |
PP2CA Polyclonal Antibody |
| Other name: |
Anti-PP2CA Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PP2CA |
| Short name: |
Anti-PP2CA (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PP2CA (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9275 |
| Gene: |
PPM1A |
More about : PPM1A |
| Long gene name: |
Mg2+/Mn2+ dependent 1A , protein phosphatase |
| Synonyms gene name: |
1A , Mg2+/Mn2+ dependent, alpha isoform protein phosphatase, magnesium-dependent, protein phosphatase 1A (formerly 2C) |
| Synonyms name: |
alpha isoform , phosphatase 2C alpha protein phosphatase 2C |
| Locus: |
14q23, 1 |
| Discovery year: |
1993-02-05 |
| GenBank acession: |
S87759 |
| Entrez gene record: |
5494 |
| Pubmed identfication: |
1311954 |
| RefSeq identity: |
NM_021003 |
| Classification: |
Mg2+/Mn2+ dependent , Protein phosphatases |
| Havana BLAST/BLAT: |
OTTHUMG00000140333 |