| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Filamin A |
| Specificity: |
This antibody reacts specifically with Filamin A |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Filamin A |
| Gene ID: |
2316 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Both muscular (CDh) and non-muscular (CDl) forms of Caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and Myosin, CDh is expressed predominantly on thin filaments in smooth muscle, Filamin 1, Filamin 1, Nebulin and Villin are differentially expressed and regulated Actin binding proteins, Nebulin is a large filamentous protein specific to muscle tissue that may function as a ruler for filament length, Several isoforms of Nebulin are produced by alternative exon usage, Villin is Ca2+-regulated and is the major structural component of the brush border of absorptive cells, functions to crosslink Actin to filaments, whereas CDl is widely expressed in non-muscle tissues and cells, which is ubiquitously expressed and exists as a homodimer, Caldesmon |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ABP-280 FLNA |
| Also known as: |
Filamin A Polyclonal Antibody |
| Other name: |
Anti-Filamin A Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Filamin A |
| Short name: |
Anti-Filamin A (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Filamin A (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3751 |
| Gene: |
FLN1 |
More about : FLN1 |
| Long gene name: |
filamin A |
| Synonyms gene: |
FLN OPD2 OPD1 |
| Synonyms gene name: |
alpha , alpha (actin binding protein 280) filamin A, filamin A |
| Synonyms name: |
actin binding protein 280 alpha filamin |
| Locus: |
Xq28 |
| Discovery year: |
1993-03-18 |
| GenBank acession: |
X70082 |
| Pubmed identfication: |
8406501 12612583 |
| Havana BLAST/BLAT: |
OTTHUMG00000022712 |
| Locus Specific Databases: |
Mental Retardation database |