| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MAVS |
| Specificity: |
This antibody reacts specifically with MAVS |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MAVS |
| Gene ID: |
5788 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Silencing of MAVS expression permits derepression of viral replication, while over expression of MAVS boosts antiviral immunity, MAVS (Mitochondrial Antiviral Signaling) mediates the activation of NF-kappaB and IRF3 in response to antiviral infection |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
VISA KIAA1271 IPS-1 Cardif |
| Also known as: |
MAVS Polyclonal Antibody |
| Other name: |
Anti-MAVS Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MAVS |
| Short name: |
Anti-MAVS (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-mitochondrial antiviral signaling protein (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BT, CARD domain binding, MAVS and IDBG-49080 and ENSG00000088888 and 57506, Mavs and IDBG-207066 and ENSMUSG00000037523 and 228607, Plasma membranes, this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002218 and activation of innate immune response and biological process this GO :0002230 and positive regulation of defense response to virus by host and biological process this GO :0004871 and signal transducer activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005777 and peroxisome and cellular component this GO :0005778 and peroxisomal membrane and cellular component this GO :0007165 and signal transduction and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0031966 and mitochondrial membrane and cellular component this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032727 and positive regulation of interferon-alpha production and biological process this GO :0032728 and positive regulation of interferon-beta production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0033160 and positive regulation of protein import into nucleus, this GO :0004871 : signal transducer activity, this GO :0004871 : signal transducer activity and also this GO :0005515 : protein binding and also this GO :0019901 : protein kinase binding and also this GO :0050700 : CARD domain binding, this GO :0005515 : protein binding, this GO :0019901 : protein kinase binding, this GO :0050700 : CARD domain binding, translocation and biological process this GO :0039529 and RIG-I signaling pathway and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0042993 and positive regulation of transcription factor import into nucleus and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0045071 and negative regulation of viral genome replication and biological process this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050700 and CARD domain binding and molecular function this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051607 and defense response to virus and biological process this GO :0060340 and positive regulation of type I interferon-mediated signaling pathway and biological process this GO :0071360 and cellular response to exogenous dsRNA and biological process this GO :0071651 and positive regulation of chemokine (C-C motif) ligand 5 production and biological process this GO :0071660 and positive regulation of IP-10 production and biological process this GO :1900063 and regulation of peroxisome organization and biological process, 45349 and IDBG-640031 and ENSBTAG00000013545 and 618508, mitochondrial antiviral signaling protein |
| Identity: |
29233 |
| Gene: |
MAVS |
More about : MAVS |
| Long gene name: |
mitochondrial antiviral signaling protein |
| Synonyms name: |
virus-induced signaling adaptor IFN-B promoter stimulator 1 CARD adaptor inducing IFN-beta |
| Locus: |
20p13 |
| Discovery year: |
2009-04-01 |
| GenBank acession: |
DQ174270 |
| Entrez gene record: |
57506 |
| Pubmed identfication: |
16125763 16153868 |
| RefSeq identity: |
NM_020746 |
| Classification: |
Caspase recruitment domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031765 |