| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
1, CACNA1A/Cav2 |
| Specificity: |
1, This antibody reacts specifically with CACNA1A/Cav2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CACNA1A |
| Gene ID: |
773 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Cav2, Cav2, In many cases, The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity, The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit, Voltage-dependent calcium channels are multisubunit complexes, alpha-2, beta and delta subunits in a 1:1:1:1 ratio, cell division and cell death, cell motility, consisting of alpha-1, gene expression, hormone or neurotransmitter release, including muscle contraction, this subunit is sufficient to generate voltage-sensitive calcium channel activity, 1 (isoform alpha-1A) gives rise to P and/or Q-type calcium currents, 1 is a voltage-sensitive calcium channels (VSCC) which belongs to the calcium channel alpha-1 subunit family, 1 mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, Cav2 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Cav2, 1 EA2 APCA HPCA FHM |
| Also known as: |
1 Polyclonal Antibody, CACNA1A/Cav2 |
| Other name: |
1 Polyclonal, Anti-CACNA1A/Cav2 |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
1, CACNA1A/Cav2 |
| Short name: |
1 (Polyclonal) Fluor 594, Anti-CACNA1A/Cav2 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, P/Q classification, a 1A subunit/Cav2, voltage-dependent, 1 (polyclonal), antibody to-calcium channel |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
APCA and BI and CACNL1A4 and CAV2, CACNA1A and IDBG-31996 and ENSG00000141837 and 100507353, CACNA1A and IDBG-642817 and ENSBTAG00000014828 and 282648, Cacna1a and IDBG-174190 and ENSMUSG00000034656 and 12286, P/Q type, alpha 1A subunit, glutamatergic and biological process this GO :0042133 and neurotransmitter metabolic process and biological process this GO :0042391 and regulation of membrane potential and biological process this GO :0042445 and hormone metabolic process and biological process this GO :0042995 and cell projection and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0043113 and receptor clustering and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048265 and response to pain and biological process this GO :0048266 and behavioral response to pain and biological process this GO :0048791 and calcium ion-dependent exocytosis of neurotransmitter and biological process this GO :0048813 and dendrite morphogenesis and biological process this GO :0050770 and regulation of axonogenesis and biological process this GO :0050796 and regulation of insulin secretion and biological process this GO :0050877 and neurological system process and biological process this GO :0050883 and musculoskeletal movement, metal ion binding, nuclei, spinal reflex action and biological process this GO :0050885 and neuromuscular process controlling balance and biological process this GO :0050905 and neuromuscular process and biological process this GO :0051899 and membrane depolarization and biological process this GO :0055085 and transmembrane transport and biological process this GO :0060024 and rhythmic synaptic transmission and biological process this GO :0070509 and calcium ion import and biological process this GO :0070588 and calcium ion transmembrane transport and biological process this GO :0086010 and membrane depolarization during action potential and biological process, this GO :0000096 and sulfur amino acid metabolic process and biological process this GO :0005216 and ion channel activity and molecular function this GO :0005244 and voltage-gated ion channel activity and molecular function this GO :0005245 and voltage-gated calcium channel activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005891 and voltage-gated calcium channel complex and cellular component this GO :0006006 and glucose metabolic process and biological process this GO :0006112 and energy reserve metabolic process and biological process this GO :0006811 and ion transport and biological process this GO :0006816 and calcium ion transport and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007214 and gamma-aminobutyric acid signaling pathway and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007270 and neuron-neuron synaptic transmission and biological process this GO :0007274 and neuromuscular synaptic transmission and biological process this GO :0007416 and synapse assembly and biological process this GO :0007628 and adult walking behavior and biological process this GO :0008219 and cell death and biological process this GO :0008331 and high voltage-gated calcium channel activity and molecular function this GO :0014051 and gamma-aminobutyric acid secretion and biological process this GO :0014056 and regulation of acetylcholine secretion and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016049 and cell growth and biological process this GO :0017156 and calcium ion-dependent exocytosis and biological process this GO :0017158 and regulation of calcium ion-dependent exocytosis and biological process this GO :0019226 and transmission of nerve impulse and biological process this GO :0019905 and syntaxin binding and molecular function this GO :0021522 and spinal cord motor neuron differentiation and biological process this GO :0021590 and cerebellum maturation and biological process this GO :0021679 and cerebellar molecular layer development and biological process this GO :0021680 and cerebellar Purkinje cell layer development and biological process this GO :0021702 and cerebellar Purkinje cell differentiation and biological process this GO :0021750 and vestibular nucleus development and biological process this GO :0021953 and central nervous system neuron differentiation and biological process this GO :0030425 and dendrite and cellular component this GO :0030644 and cellular chloride ion homeostasis and biological process this GO :0032353 and negative regulation of hormone biosynthetic process and biological process this GO :0034220 and ion transmembrane transport and biological process this GO :0034765 and regulation of ion transmembrane transport and biological process this GO :0035249 and synaptic transmission, this GO :0005216 : ion channel activity, this GO :0005216 : ion channel activity and also this GO :0005244 : voltage-gated ion channel activity and also this GO :0005245 : voltage-gated calcium channel activity and also this GO :0005515 : protein binding and also this GO :0008331 : high voltage-gated calcium channel activity and also this GO :0019905 : syntaxin binding and also this GO :0046872 : metal ion binding, this GO :0005244 : voltage-gated ion channel activity, this GO :0005245 : voltage-gated calcium channel activity, this GO :0005515 : protein binding, this GO :0008331 : high voltage-gated calcium channel activity, this GO :0019905 : syntaxin binding, this GO :0046872 : metal ion binding, voltage-dependent, 1 and EA2 and FHM and HPCA and MHP and MHP1 and SCA6, 773, calcium channel |
| Identity: |
1388 |
| Gene: |
CACNA1A |
More about : CACNA1A |
| Long gene name: |
calcium voltage-gated channel subunit alpha1 A |
| Synonyms gene: |
CACNL1A4 SCA6 MHP1 MHP |
| Synonyms gene name: |
P/Q type, alpha 1A subunit , calcium channel, voltage-dependent |
| Locus: |
19p13, 13 |
| Discovery year: |
1996-06-18 |
| GenBank acession: |
U79666 |
| Entrez gene record: |
773 |
| Pubmed identfication: |
8825650 16382099 23827678 |
| RefSeq identity: |
NM_000068 |
| Classification: |
Calcium voltage-gated channel subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000044590 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database Familial Hemiplegic Migraine (FHM) Variation Database LRG_7 |