| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
DIO2 |
| Specificity: |
This antibody reacts specifically with DIO2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human DIO2 |
| Gene ID: |
1734 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
DIO2 is expressed in heart, It is essential for providing the brain with appropriate levels of T3 during the critical period of development, There are two named isoforms, fetal brain and several regions of the adult brain, placenta, skeletal muscle, 3', 3'-triiodothyronine), 5, 5, 5'-tetraiodothyronine) into T3 (3, DIO2 belongs to the iodothyronine deiodinase family and is responsible for the deiodination of T4 (3 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TXDI2 SelY |
| Also known as: |
DIO2 Polyclonal Antibody |
| Other name: |
Anti-DIO2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
DIO2 |
| Short name: |
Anti-DIO2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, iodothyronine, type II (polyclonal), antibody to-deiodinase |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
5DII and D2 and DIOII and SelY and TXDI2, DIO2 and IDBG-14346 and ENSG00000211448 and 1734, DIO2 and IDBG-646906 and ENSBTAG00000001605 and 494548, Dio2 and IDBG-161130 and ENSMUSG00000007682 and 13371, Plasma membranes, iodothyronine, this GO :0001514 and selenocysteine incorporation and biological process this GO :0004800 and thyroxine 5'-deiodinase activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006590 and thyroid hormone generation and biological process this GO :0008430 and selenium binding and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016209 and antioxidant activity and molecular function this GO :0016491 and oxidoreductase activity and molecular function this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0034641 and cellular nitrogen compound metabolic process and biological process this GO :0042403 and thyroid hormone metabolic process and biological process this GO :0042404 and thyroid hormone catabolic process and biological process this GO :0042446 and hormone biosynthetic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0055114 and oxidation-reduction process and biological process, this GO :0004800 : thyroxine 5'-deiodinase activity, this GO :0004800 : thyroxine 5'-deiodinase activity and also this GO :0008430 : selenium binding and also this GO :0016209 : antioxidant activity and also this GO :0016491 : oxidoreductase activity and also this GO :0031625 : ubiquitin protein ligase binding, this GO :0008430 : selenium binding, this GO :0016209 : antioxidant activity, this GO :0016491 : oxidoreductase activity, this GO :0031625 : ubiquitin protein ligase binding, type II, ubiquitin protein ligase binding, deiodinase |
| Identity: |
2884 |
| Gene: |
DIO2 |
More about : DIO2 |
| Long gene name: |
iodothyronine deiodinase 2 |
| Synonyms gene name: |
deiodinase, iodothyronine type II |
| Synonyms name: |
thyroxine deiodinase, type II deiodonase-2 deiodinase-2 |
| Locus: |
14q31, 1 |
| Discovery year: |
1997-05-09 |
| GenBank acession: |
AF007144 |
| Entrez gene record: |
1734 |
| Pubmed identfication: |
8755651 10343107 |
| Classification: |
Selenoproteins |
| Havana BLAST/BLAT: |
OTTHUMG00000171443 |