| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HSP22 |
| Specificity: |
This antibody reacts specifically with HSP22 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HSP22 |
| Gene ID: |
26353 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Hsp22 is a monomeric protein which interacts with HSPB1, It displays temperature-dependent chaperone activity, Mutations in the HSPB8 gene are associated with the inherited peripheral neuropathies, The highest abundance of Hsp22 is in skeletal muscle, and placenta, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L), heart, Hsp22 (HSPB8) is a 196-amino acid protein that contains a central portion homologous to a highly conserved HSP-alpha crystallin domain common to all the small heat shock protein (HSP20) family members |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
H11 E2IG1 HSP22 HspB8 CMT2L |
| Also known as: |
HSP22 Polyclonal Antibody |
| Other name: |
Anti-HSP22 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HSP22 |
| Short name: |
Anti-HSP22 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HSP22 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
30171 |
| Gene: |
HSPB8 |
More about : HSPB8 |
| Long gene name: |
heat shock protein family B (small) member 8 |
| Synonyms gene name: |
heat shock 27kDa protein 8 heat shock 22kDa protein 8 |
| Locus: |
12q24, 23 |
| Discovery year: |
2004-01-29 |
| GenBank acession: |
AF191017 |
| Entrez gene record: |
26353 |
| Pubmed identfication: |
10833516 11085516 |
| RefSeq identity: |
NM_014365 |
| Classification: |
Small heat shock proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000168932 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_249 |